Structure-antimicrobial activity relationship and action mechanism of dimeric quaternary ammonium amphiphiles
- 10.2991/ic3me-15.2015.82How to use a DOI?
- Dimeric quaternary ammonium, Antimicrobial, Escherichia coli.
The antibacterial activity of the five dimeric quaternary ammonium amphiphiles against Escherichia coli were evaluated by determining the minimum inhibitory concentration (MIC) and compared with one monomeric quaternary ammonium amphiphile. The antibacterial activity of dimeric amphiphiles is superior to the corresponding monomeric amphiphile. The action mechanism was investigated by measuring the activity of -galactosidase from E. coli and scanning electron microscopy (SEM) imaging of E. coli cells. The result of -galactosidase activity shows that 12-8-12 disrupts the membrane of E.coli leading to the releasing of intracellular contents and death of bacterial cells. This conclusion was supported by scanning electron microscopy, which imaged the holes on the cell membrane and irregular shape of cells caused by treatment of 12-8-12.
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Xiao Fang Zhao AU - Ya Hong Li AU - Hao Yuan PY - 2015/08 DA - 2015/08 TI - Structure-antimicrobial activity relationship and action mechanism of dimeric quaternary ammonium amphiphiles BT - Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering PB - Atlantis Press SP - 417 EP - 420 SN - 2352-5401 UR - https://doi.org/10.2991/ic3me-15.2015.82 DO - 10.2991/ic3me-15.2015.82 ID - Zhao2015/08 ER -