Research and Exploration of Programmed Cell Death in Infectious Diseases

DOI

10.2991/978-2-38476-253-8_70How to use a DOI?

Keywords

Infectious diseases; programmed cell death; apoptosis; pyroptosis; ferroptosis; necroptosis

Abstract

Cell death is a fundamental biological phenomenon that is essential for the survival and development of living organisms. Cell death can be either a spontaneous programmed host process or an accidentally triggered process. Programmed cell death presents a lysed/non-lytic cell morphology depending on the signaling pathway activated by the stimulus. For example, apoptosis is characterized by cell shrinkage and the formation of apoptotic bodies, which is a typical non-lytic death mode. However, cysteine aspartate-specific protease 1/11-mediated pyroptosis and necroptotic processes can cause inflammatory responses, and promote cell lysis and release inflammatory cytokines by triggering the membrane pore-forming mechanism, which is a typical lytic death mode. In addition, the mitochondrial damage process triggered during the pathogen infection phase can further induce the release of intracellular reactive oxygen species, which in turn triggers ferroptosis. Studies have shown that these programmed cell death modalities can exert immune defense by eliminating infected cells and pathogens within cells, and stimulating an innate immune response with the help of the resulting cell cadavers. In this review, we summarize the molecular mechanisms of multiple cell death pathways and their roles in the defense of innate immunity against microbial infection, and briefly elaborate the interactions between different programmed cell death pathways, in order to provide new ideas for further study of the pathogenic mechanism of infectious diseases.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Hao Li
PY  - 2024
DA  - 2024/05/28
TI  - Research and Exploration of Programmed Cell Death in Infectious Diseases
BT  - Proceedings of the 2024 3rd International Conference on Humanities, Wisdom Education and Service Management (HWESM 2024)
PB  - Atlantis Press
SP  - 585
EP  - 592
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-253-8_70
DO  - 10.2991/978-2-38476-253-8_70
ID  - Li2024
ER  -