Synthesis of Novel pH-responsive PEGylated Zwitterionic Triblock Copolymer

DOI

10.2991/bst-16.2016.43How to use a DOI?

Keywords

Self-assembly, Triblock copolymer, pH-responsive, ATRP.

Abstract

Well-defined PEGylated zwitterionic triblock copolymer, poly(ethylene glycol)-b-poly¬¬¬¬(methacrylic acid)-b-poly(2-aminoethyl methacrylate) (PEG-b-PMAA-b -PAEMA), was prepar¬e¬d from poly(ethylene glycol)-b-poly(tert-butyl meth acrylate) -b-poly(N-(tert-butoxycarbonyl)¬¬¬¬ amino ethyl methacrylate)(PEG-b-PtBocMA-b-PtBoc AEMA) precursor synthesized via atom tra¬ns¬e¬r radical polymerization (ATRP) by successively polymerized tert-butyl methacrylate (tBocM¬A) and N-(tert-butoxy- carbonyl) amionethyl methacrylate (tBocAEMA) monomers using a PEG-bas¬e¬d macro- initiator followed by t-Boc group deprotection. The obtained triblock copolymer was conf¬ir¬med by proton nuclear magnetic response (1H NMR) and Gel Permeation Chromatography (GPC). The resultant PEG-b-PMAA-b-PAEMA copolymer bearing a large number of amine moiet¬i¬es will have potential applications as anti-cancer drug or DNA carriers.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Hai-Liang Dong
AU  - Zhong-Li Niu
AU  - Xiao-Ting Zhang
AU  - Shu-Yu Zhu
AU  - Ying Yao
AU  - Ya Gao
AU  - Bin Sun
AU  - Mei-Fang Zhu
AU  - Xiao-Ze Jiang
PY  - 2016/01
DA  - 2016/01
TI  - Synthesis of Novel pH-responsive PEGylated Zwitterionic Triblock Copolymer
BT  - Proceedings of the 2016 International Conference on Biological Sciences and Technology
PB  - Atlantis Press
SP  - 290
EP  - 294
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-16.2016.43
DO  - 10.2991/bst-16.2016.43
ID  - Dong2016/01
ER  -