Influence of Tonifying Kidney and Spleen, Detoxification of Throat Method to TNF-α, IL-6 of IgA Nephropathy Model Rat

DOI

10.2991/bbe-16.2016.37How to use a DOI?

Keywords

Tonifying Kidney and Spleen, Detoxification of Throat Method, IgA nephropathy, Model rats, TNF-α, IL-6.

Abstract

Purpose: To study the effect and function mechanism of Tonifying Kidney and Spleen, Detoxification of Throat method on IgA nephropathy. Methods: the 72 Wistar rats were randomly divided into blank group, model group, Lotensin group, Tonifying kidney and spleen, detoxification of throat high, medium and low dose group (which is called traditional Chinese medicine high, medium and low dose group for short). The IgA nephropathy rat model were established by the method of feeding with bovine serum albumin (BSA) and injecting tail vein with lipopolysaccharide (LPS).After Eight weeks administration, each phase's urine red blood cell count, 24h UTP, TNF-α and IL-6 content were observed. Results: compared with model group, every groups' UTP decreased and TCM medium dose group decreased extraordinary (P<0.05);compared with model group, urine red blood cell count decreased significantly of every TCM group(P<0.05), especially TCM medium dose group improved significantly (P<0.01), but Lotensin group urine red blood cell count no drop (P>0.05); compared with blank group, TNF-α,IL-6 of model group's were significantly elevated (P<0.05);compared with model group, TNF-α,IL-6 of treatment groups decreased significantly(P<0.05),compared between TCM group, TCM medium dose group's data is the most significant(P<0.01).Conclusion: Tonifying kidney and spleen, detoxification of throat method can reduce hematuria and proteinuria of IgA nephropathy model rats, and reduce the content of IL-6 and TNF-α in serum which is better than Lotensin.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Di Zou
AU  - Yinping Wang
AU  - Dongmei Zhang
AU  - Shoulin Zhang
PY  - 2016/07
DA  - 2016/07
TI  - Influence of Tonifying Kidney and Spleen, Detoxification of Throat Method to TNF-α, IL-6 of IgA Nephropathy Model Rat
BT  - Proceedings of the 2016 International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SP  - 221
EP  - 225
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.37
DO  - 10.2991/bbe-16.2016.37
ID  - Zou2016/07
ER  -