Biotherapy Effect of Shenfuweikang Herbs on Gastric Carcinoma

DOI

10.2991/bbe-16.2016.16How to use a DOI?

Keywords

Biotherapy, Shenfuweikang, Cytotoxicity, Immunity, Gastric cancer.

Abstract

To study the biotherapy effect of Shenfuweikang herbs in treatment of gastric cancer, Kunming mice were grafted with a mouse gastric adenocarcinoma cell line MFC. Mice received different doses of Shefuweikang herbs after grafting. Tumor size was periodically measured and tumor weight was determined after the animals sacrificed. Apoptotic indices (AI) were examined by TUNEL assay and flow cytometric analysis. Serum cytokines IFN- and granzyme B were detected by ELISA. The anti-tumor effect was determined by the cytotoxic T-lymphocyte (CTL) assays. Our results demonstrated that Shefuweikang herbs could induce apoptosis and inhibit the growth of gastric cancer by activating the CTLs and eliciting the secretion of cytokines, IFN- and granzyme B. Our study suggests that Shefuweikang herbs inhibit the proliferation of gastric carcinoma by inducing the apoptosis of tumor cells and activating the effects of immune cells, which may lay a better basis for further study on gastric cancer biotherapy

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Xiaoping Wang
AU  - Huanping Lin
AU  - Qiaoxia Wang
AU  - Bing Xu
AU  - Yi Li
AU  - Baoning Qi
AU  - Xuxu Wei
AU  - Pengfei Zhang
PY  - 2016/07
DA  - 2016/07
TI  - Biotherapy Effect of Shenfuweikang Herbs on Gastric Carcinoma
BT  - Proceedings of the 2016 International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SP  - 90
EP  - 96
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.16
DO  - 10.2991/bbe-16.2016.16
ID  - Wang2016/07
ER  -