Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)

Memory Impairment in A?' (25-35) and D-Galactose Induced Alzheimer’s Disease Model Rat

Authors
Feijuan Huang, Fang Bai, Mengzhou Xie, Xianxiang Tian, Weiping Li, Yinghong Li, Jiangang Shen, Zhengzhi Wu, Jian Qin
Corresponding Author
Feijuan Huang
Available Online April 2018.
DOI
https://doi.org/10.2991/bbbs-18.2018.42How to use a DOI?
Keywords
Alzheimer disease; Beta amyloid; neuronal cells damage in the brain.
Abstract

Beta amyloid (Aβ) is a key pathological hallmark of Alzheimer disease (AD) and plays key roles the progressive process of this disease. However the involved biological processes or pathways that triggered by Aβ in the progress of AD are still unclear. To answer this question, Aβ25-35 was bilaterally injected into the rats’ bilateral hippocampus and to accelerate the brain aging, d-gal was subcutaneously administrated, so as to set up the combined AD model rats and further explore the gene expression profile of the rats. The results demonstrated that the d-gal and Aβ treatment led to learning and memory impairment in behavioral test and neuronal cells damage in the brain, which validated the establishment of AD model rats. These verified genes may provide a new insight for elucidating Aβ cascade hypothesis in AD and its progression.

Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
Series
Advances in Biological Sciences Research
Publication Date
April 2018
ISBN
978-94-6252-511-5
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbbs-18.2018.42How to use a DOI?
Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Feijuan Huang
AU  - Fang Bai
AU  - Mengzhou Xie
AU  - Xianxiang Tian
AU  - Weiping Li
AU  - Yinghong Li
AU  - Jiangang Shen
AU  - Zhengzhi Wu
AU  - Jian Qin
PY  - 2018/04
DA  - 2018/04
TI  - Memory Impairment in A?' (25-35) and D-Galactose Induced Alzheimer’s Disease Model Rat
BT  - Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
PB  - Atlantis Press
SP  - 197
EP  - 201
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbbs-18.2018.42
DO  - https://doi.org/10.2991/bbbs-18.2018.42
ID  - Huang2018/04
ER  -