Memory Impairment in A?' (25-35) and D-Galactose Induced Alzheimer’s Disease Model Rat
- https://doi.org/10.2991/bbbs-18.2018.42How to use a DOI?
- Alzheimer disease; Beta amyloid; neuronal cells damage in the brain.
Beta amyloid (Aβ) is a key pathological hallmark of Alzheimer disease (AD) and plays key roles the progressive process of this disease. However the involved biological processes or pathways that triggered by Aβ in the progress of AD are still unclear. To answer this question, Aβ25-35 was bilaterally injected into the rats’ bilateral hippocampus and to accelerate the brain aging, d-gal was subcutaneously administrated, so as to set up the combined AD model rats and further explore the gene expression profile of the rats. The results demonstrated that the d-gal and Aβ treatment led to learning and memory impairment in behavioral test and neuronal cells damage in the brain, which validated the establishment of AD model rats. These verified genes may provide a new insight for elucidating Aβ cascade hypothesis in AD and its progression.
- © 2018, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Feijuan Huang AU - Fang Bai AU - Mengzhou Xie AU - Xianxiang Tian AU - Weiping Li AU - Yinghong Li AU - Jiangang Shen AU - Zhengzhi Wu AU - Jian Qin PY - 2018/04 DA - 2018/04 TI - Memory Impairment in A?' (25-35) and D-Galactose Induced Alzheimer’s Disease Model Rat BT - Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018) PB - Atlantis Press SP - 197 EP - 201 SN - 2468-5747 UR - https://doi.org/10.2991/bbbs-18.2018.42 DO - https://doi.org/10.2991/bbbs-18.2018.42 ID - Huang2018/04 ER -