Study on Aldose Reductase Inhibitors Based on Quinoxalin Structure

DOI

10.2991/bbbs-18.2018.29How to use a DOI?

Keywords

Inhibition and inoxidizability; carboxyl group; hydroxy phenol.

Abstract

The purpose of this study is to design and synthesize a multifunctional aldose reductase inhibitor with both aldose reductase inhibitory activity and direct antioxidant activity. Based on the quinoxalin structure, we modify side chain of C3-N1. Specifically, the activity of N-1 is further enhanced by the introduction of carboxyl group. And the hydroxy phenol was introduced to the C-3 position. And then test external biological activity to confirm its reductase inhibition and inoxidizability. Finally, the synthetic compounds were analyzed and demonstrated by molecular simulation. The target compound had an aldose reductase IC50 of 26.5 nM. Also we use the software of Molecule docking to explain the rationality of the design.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yang Li
AU  - Bing Ma
PY  - 2018/04
DA  - 2018/04
TI  - Study on Aldose Reductase Inhibitors Based on Quinoxalin Structure
BT  - Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
PB  - Atlantis Press
SP  - 133
EP  - 136
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbbs-18.2018.29
DO  - 10.2991/bbbs-18.2018.29
ID  - Li2018/04
ER  -