Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)

Research study on target treatment of ultrasound microbubbles with docetaxel on osteosarcoma

Authors
Dan Fei, Yang Li, Guoqing Sui
Corresponding Author
Dan Fei
Available Online April 2018.
DOI
https://doi.org/10.2991/bbbs-18.2018.5How to use a DOI?
Keywords
Ultrasound; Micro bubble; Docetaxel; Osteosarcoma
Abstract

To investigate the therapeutic effect of target treatment on osteosarcoma cells through ultrasound micro bubble imaging with docetaxel. Methods The osteosarcoma model of Sprague-Dawley rats was established by implantation of tissue mass of UMR-106 cell line on the back. The model rats were randomly divided into 3 groups after modeling: the group of ultrasound micro bubbles with docetaxel, the group of docetaxel, and the control group. Three groups were given drugs once a week and stopped after 5 weeks of administration. The tumor mass weight was taken out to calculate the tumor inhibition rate within 24 hours after drug withdrawal. The difference of the parameters among the groups was analyzed by SPSS17.0 software. Results Targeted treatment of ultrasound micro bubble imaging with docetaxel could significantly inhibit the growth of osteosarcoma, and the inhibition rates of each experimental group were 24.2% and 12.1%, respectively, indicating its significant function on inhibiting the growth of osteosarcoma cells. Compared with the experimental groups, the tumor inhibition rates among the experimental groups were statistically significant (P < 0.05). Conclusion Docetaxel has a significant function on inhibiting the growth of osteosarcoma. Target treatment of ultrasound micro bubbles with docetaxel is conducive to improve the therapeutic effect and further achieve the purpose of targeted therapy

Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
Series
Advances in Biological Sciences Research
Publication Date
April 2018
ISBN
978-94-6252-511-5
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbbs-18.2018.5How to use a DOI?
Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Dan Fei
AU  - Yang Li
AU  - Guoqing Sui
PY  - 2018/04
DA  - 2018/04
TI  - Research study on target treatment of ultrasound microbubbles with docetaxel on osteosarcoma
BT  - Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
PB  - Atlantis Press
SP  - 19
EP  - 22
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbbs-18.2018.5
DO  - https://doi.org/10.2991/bbbs-18.2018.5
ID  - Fei2018/04
ER  -