Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)

Observation of synergistic effect of End statin and cisplatin On Calu-6 cell

Authors
Xin Cheng, Qiuju Lin, Wenhui Li
Corresponding Author
Xin Cheng
Available Online April 2018.
DOI
https://doi.org/10.2991/bbbs-18.2018.4How to use a DOI?
Keywords
End statin, Calu-6, apoptosis
Abstract

End statin is an endogenous inhibitor of angiogenesis, specifically acting on endothelial cells, inhibiting its migration, inducing its apoptosis, thus inhibiting the forming of new vessels and tumor growth. But it is not clear about the synergetic mechanism, action characteristic and best regimen. This paper we choosing Calu-6, the human lung adenocarcinoma cell, to observe end statin with/without cisplatin inhibiting growth and inducing apoptosis and the synergetic effect, to provide the experimental evidence for clinical application. The result indicated that End statin can inhibit growth of Calu-6 cell and induce its apoptosis with the mechanism concerned with the down-regulation of Bcl-2. End statin has synergistic effect with Cisplatin, especially in simultaneous administration of two drugs. End statin maybe has an optimistic dosage of action. The mechanisms of End statins’ effect are similar

Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

Volume Title
Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
Series
Advances in Biological Sciences Research
Publication Date
April 2018
ISBN
978-94-6252-511-5
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbbs-18.2018.4How to use a DOI?
Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Xin Cheng
AU  - Qiuju Lin
AU  - Wenhui Li
PY  - 2018/04
DA  - 2018/04
TI  - Observation of synergistic effect of End statin and cisplatin On Calu-6 cell
BT  - Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
PB  - Atlantis Press
SP  - 15
EP  - 18
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbbs-18.2018.4
DO  - https://doi.org/10.2991/bbbs-18.2018.4
ID  - Cheng2018/04
ER  -