Progress in Chemotherapy of Malignant Bone Tumors

DOI

10.2991/asssd-18.2018.40How to use a DOI?

Keywords

Bone tumors/ drug therapy; tumor metastasis; prognosis

Abstract

In the past 30 years, great progress has been achieved in the treatment of malignant bone tumors, which must be significantly attributed to the application and gradual improvement of chemotherapy, especially the appearance of neo-adjuvant chemotherapy concept and the application of its rules. Represented by osteosarcoma and Ewing’s sarcoma, malignant bone tumors mainly relied on amputation, local wide resection and sufficient radiation therapy before the appearance of chemotherapy, and these conventional therapies often resulted in the lifelong disability of patients and very high local recurrence rate. Moreover, the 5-year survival rate was less than 20%. However, neo-adjuvant chemotherapy brings the hope for patients with malignant bone tumors to keep their extremities and functions, and the 5-year survival rate in foreign countries exceeds 80% [1], while the 5-year survival rate reported in China also reached 50%~60% [2]. The principles and methods of tumor chemotherapy are concluded from numerous clinical practices, which is divided in the following stages: single-drug adjuvant chemotherapy; multiple-drug combination chemotherapy and chemotherapeutic application of maximum tolerated dose (dose-intensity); application of (adjuvant) chemotherapy during clinical metastasis of disease; application of (neo-adjuvant) chemotherapy prior to other treatment.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Rui Jiang
AU  - Ziyan Zhang
AU  - Han Wu
AU  - Chao Zhang
PY  - 2018/05
DA  - 2018/05
TI  - Progress in Chemotherapy of Malignant Bone Tumors
BT  - Proceedings of the 2018 International Conference on Advances in Social Sciences and Sustainable Development (ASSSD 2018)
PB  - Atlantis Press
SP  - 185
EP  - 190
SN  - 2352-5398
UR  - https://doi.org/10.2991/asssd-18.2018.40
DO  - 10.2991/asssd-18.2018.40
ID  - Jiang2018/05
ER  -