Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)

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The Influence of Cissus quadrangula Salisb Extract to Bone Length and the Number of Osteoblast in Femur of DDY Mice

Authors
Hendri Priyadi, Fransiska Ambarukmi Pontjosudargo, Irmadella, Alif Pascal
Corresponding Author
Hendri Priyadi
Available Online 24 July 2021.
DOI
10.2991/ahsr.k.210723.015How to use a DOI?
Keywords
Cissus quadrangular Salibs, bone length, osteoblast, femur
Abstract

Cissus quadrangula Salibs have been proven to have an influence on the growth of bone and the healing process in fractures and prevent osteoporosis. Cissus quadrangula Salibs has been widely used as traditional medicine and has proven to increase osteoblast activity, and could accelerate the recovery of bone fractures. The study aimed to assess the effect of the stem of Cissus quadrangula Salibs on the growth of bone length and the number of osteoblast cells in mice femur. This study used a comparative method with a completely randomized design of 24 mice which were divided into 4 groups. P0 is a control group that is only given standard food, while P1 to P3 are the treatment groups given Cissus quadrangula Salibs extracts at doses of 500 mg/Kg BW, 700 mg/Kg BW, and 900 mg/Kg BW. The extract was given for 30 days, then measured the length of the bone and the number of osteoblasts on the metaphyseal plate of mice femur. Data were analyzed using One Way ANOVA and Post Hoc Duncan’s test with a 95% degree of confidence. The results showed that Cissus quadrangula Salibs extract at a dose of 700 mg/Kg BW and 900 mg/Kg BW affects the length of the femur and the number of osteoblasts was significantly higher (p <0.005) than the control group. It can be concluded that Cissus quadrangula Salibs extract has the effect of increasing the length growth and number of osteoblasts Os. Femur in DDY strain mice.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)
Series
Advances in Health Sciences Research
Publication Date
24 July 2021
ISBN
10.2991/ahsr.k.210723.015
ISSN
2468-5739
DOI
10.2991/ahsr.k.210723.015How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Hendri Priyadi
AU  - Fransiska Ambarukmi Pontjosudargo
AU  - Irmadella
AU  - Alif Pascal
PY  - 2021
DA  - 2021/07/24
TI  - The Influence of Cissus quadrangula Salisb Extract to Bone Length and the Number of Osteoblast in Femur of DDY Mice
BT  - Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)
PB  - Atlantis Press
SP  - 60
EP  - 63
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210723.015
DO  - 10.2991/ahsr.k.210723.015
ID  - Priyadi2021
ER  -