Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)

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Flavonoid-Rutin Effect to Blood Glucose Level and Pancreas Regeneration in Diabetic Rats

Authors
Iis Inayati Rakhmat, Euis Reni Yuslianti, Teja Koswara
Corresponding Author
Iis Inayati Rakhmat
Available Online 24 July 2021.
DOI
10.2991/ahsr.k.210723.016How to use a DOI?
Keywords
diabetes, blood glucose, pancreatic regeneration, flavonoid
Abstract

Diabetes mellitus is chronic metabolic disorder characterized by hyperglycemic state triggers by the formation of cells free radical. Rutin as a flavonoid or secondary antioxidant can increase insulin secretion and stimulate pancreatic progenitor cells. This study aims to analyze the effect of flavonoid-rutin to decrease blood glucose levels and pancreas regeneration in diabetic rats induced by streptozotocin. Research model was a laboratory experimental and total sample 25 experimental animals consisting of 5 groups those are negative control (NC), positive control (PC), Flavonoid-flavonoid-rutin 25mg/kgBW (P1), Flavonoid-rutin 50mg/kgBW (P2), and Flavonoid-rutin 100mg/kgBW (P3). The study was conducted for 17 days by examination of blood glucose levels and pancreas regeneration. Data were analyzed Anova and Duncan (P<0,05). The results showed flavonoid-rutin 50 mg/kgBW can reduce blood glucose levels and regenerate the pancreas because has the ability to reduce free radicals that increase in conditions of hyperglycemia.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)
Series
Advances in Health Sciences Research
Publication Date
24 July 2021
ISBN
10.2991/ahsr.k.210723.016
ISSN
2468-5739
DOI
10.2991/ahsr.k.210723.016How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Iis Inayati Rakhmat
AU  - Euis Reni Yuslianti
AU  - Teja Koswara
PY  - 2021
DA  - 2021/07/24
TI  - Flavonoid-Rutin Effect to Blood Glucose Level and Pancreas Regeneration in Diabetic Rats
BT  - Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)
PB  - Atlantis Press
SP  - 64
EP  - 66
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210723.016
DO  - 10.2991/ahsr.k.210723.016
ID  - Rakhmat2021
ER  -