Modern Methods of Etiotropic Therapy and Preventive Measures in Dogs Suffering Dirofilariasis

DOI

10.2991/agrosmart-18.2018.18How to use a DOI?

Keywords

dog, zoonosis, dirofilariasis, etiotropic therapy, preventive measures

Abstract

The paper presents the core findings of a study aimed at therapeutic efficacy of domestic antiparasitics such as Inspector Total C and Helmimax on the basis of moxidectin used for etiotropic therapy and prevention of dirofilariasis in dogs. The dogs were infested by D. immitis and D. repens nematodes under natural conditions. The microfilariae were identified using blood smear technique, the concentration method (Yastrebov 2004) and the filtration through membrane filters Millipore® (Ireland). An antigen of adult mature dirofilaria was detected using Immuno Run Antigen Detection Kit CANINE HEARTWORM produced by Biogal (Israel). There were selected 57 dogs of different breeds aged 1 to 14 years. They were spontaneously infested by dirofilariasis in natural conditions and three groups were formed. Dogs from Group I (n=21) placebo were used for negative control. Dogs from Group II (n=19) were given the drug Inspector Total C once at a dose of 2.5 mg/kg (spot on). Dogs from Group III (n=17) were given the drug Helmimax once at a dose of 0.25 mg/kg (per os). Before and after the introduction of preparations, the animals have gone through clinical and hemolarvoscopic examinations on the 3rd, 14th, 30th, 45th and 60th day. It was established that domestic antiparasitics Inspector Total C and Helmimax on the basis of moxidectin in the above mentioned doses result in 100% death of microfilariae on the 3rd day after treatment regardless of the intensity of infection and the type of helminth. When used in mono mode for the period of three months, it leads to complete elimination of imaginal forms. Anthelmintics do not cause side effects and are well tolerated by animals.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Nadezhda Bespalova
AU  - Sergey Semenov
AU  - Tatyana Zolotykh
PY  - 2018/12
DA  - 2018/12
TI  - Modern Methods of Etiotropic Therapy and Preventive Measures in Dogs Suffering Dirofilariasis
BT  - International scientific and practical conference "AgroSMART - Smart solutions for agriculture" (AgroSMART 2018)
PB  - Atlantis Press
SP  - 90
EP  - 94
SN  - 2352-5401
UR  - https://doi.org/10.2991/agrosmart-18.2018.18
DO  - 10.2991/agrosmart-18.2018.18
ID  - Bespalova2018/12
ER  -