Journal of Nonlinear Mathematical Physics

Volume 18, Issue Supplement 2, December 2011, Pages 397 - 410

Bayesian Approach to the Determination of the Kinetic Parameters of DNA Hairpins Under Tension

Authors
Marco Ribezzi-Crivellari*, , §, Mario Wagner, Felix Ritort, ,
*Dipartimento di Fisica, Universitá di Roma 3, Via della Vasca Navale 84, Roma 00146, Italy
Small Biosystems Lab, Departament de Fisica Fonamental, Universitat de Barcelona, Av. Diagonal 647, 08028 Barcelona, Spain
CIBER-BBN de Bioingenieria, Biomateriales y Nanomedicina, Instituto de Sanidad Carlos III, Madrid, Spain
Received 5 November 2010, Accepted 2 March 2011, Available Online 7 January 2021.
DOI
10.1142/S1402925111001593How to use a DOI?
Keywords
Optical tweezers; Bayesian reasoning; DNA hairpins
Abstract

In this paper we propose a Bayesian scheme for the determination of the unfolding and refolding kinetic rates of DNA hairpins under tension. This method is based on the hypothesis that the unfolding-refolding dynamics is well described by a Markov Chain. The results from the Bayesian method are contrasted to widely used techniques and good agreement is found. This work can be seen as a validation of the standard techniques from a statistical point of view.

Copyright
© 2011 The Authors. Published by Atlantis Press and Taylor & Francis
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Journal of Nonlinear Mathematical Physics
Volume-Issue
18 - Supplement 2
Pages
397 - 410
Publication Date
2021/01/07
ISSN (Online)
1776-0852
ISSN (Print)
1402-9251
DOI
10.1142/S1402925111001593How to use a DOI?
Copyright
© 2011 The Authors. Published by Atlantis Press and Taylor & Francis
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Marco Ribezzi-Crivellari
AU  - Mario Wagner
AU  - Felix Ritort
PY  - 2021
DA  - 2021/01/07
TI  - Bayesian Approach to the Determination of the Kinetic Parameters of DNA Hairpins Under Tension
JO  - Journal of Nonlinear Mathematical Physics
SP  - 397
EP  - 410
VL  - 18
IS  - Supplement 2
SN  - 1776-0852
UR  - https://doi.org/10.1142/S1402925111001593
DO  - 10.1142/S1402925111001593
ID  - Ribezzi-Crivellari2021
ER  -