Volume 18, Issue Supplement 2, December 2011, Pages 397 - 410
Bayesian Approach to the Determination of the Kinetic Parameters of DNA Hairpins Under Tension
Authors
Marco Ribezzi-Crivellari*, †, §, Mario Wagner†, Felix Ritort†, ‡, ¶
*Dipartimento di Fisica, Universitá di Roma 3, Via della Vasca Navale 84, Roma 00146, Italy
†Small Biosystems Lab, Departament de Fisica Fonamental, Universitat de Barcelona, Av. Diagonal 647, 08028 Barcelona, Spain
‡CIBER-BBN de Bioingenieria, Biomateriales y Nanomedicina, Instituto de Sanidad Carlos III, Madrid, Spain
Received 5 November 2010, Accepted 2 March 2011, Available Online 7 January 2021.
- DOI
- 10.1142/S1402925111001593How to use a DOI?
- Keywords
- Optical tweezers; Bayesian reasoning; DNA hairpins
- Abstract
In this paper we propose a Bayesian scheme for the determination of the unfolding and refolding kinetic rates of DNA hairpins under tension. This method is based on the hypothesis that the unfolding-refolding dynamics is well described by a Markov Chain. The results from the Bayesian method are contrasted to widely used techniques and good agreement is found. This work can be seen as a validation of the standard techniques from a statistical point of view.
- Copyright
- © 2011 The Authors. Published by Atlantis Press and Taylor & Francis
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Marco Ribezzi-Crivellari AU - Mario Wagner AU - Felix Ritort PY - 2021 DA - 2021/01/07 TI - Bayesian Approach to the Determination of the Kinetic Parameters of DNA Hairpins Under Tension JO - Journal of Nonlinear Mathematical Physics SP - 397 EP - 410 VL - 18 IS - Supplement 2 SN - 1776-0852 UR - https://doi.org/10.1142/S1402925111001593 DO - 10.1142/S1402925111001593 ID - Ribezzi-Crivellari2021 ER -