How the Mutational-Selection Interplay Organizes the Fitness Landscape

DOI

10.1142/S1402925111001532How to use a DOI?

Keywords

Fitness; natural selection; mutation; quasi species

Abstract

Fundamental questions posed in classical genetics since early 20th century are still fundamental in today post genomic age. What has changed is the availability of huge amount of molecular genetics information on a broad spectrum of species and a more powerful and rich methodological approach, particularly that one based on statistical mechanics and dynamical system theory which is providing unprecedented prediction power. Here we focus on the behavior of basic life forms such as bacteria and viruses which have small genomes and short generation times. We show that central issues of the evolutionary theory, i.e. how genotype, phenotype and fitness are related, the effect of positive and negative natural selection, the specie formation could be described by simple models which allow predictions and validation using experimental data.

Copyright

© 2011 The Authors. Published by Atlantis Press and Taylor & Francis

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Franco Bagnoli
AU  - Píetro Lió
PY  - 2021
DA  - 2021/01/07
TI  - How the Mutational-Selection Interplay Organizes the Fitness Landscape
JO  - Journal of Nonlinear Mathematical Physics
SP  - 265
EP  - 286
VL  - 18
IS  - Supplement 2
SN  - 1776-0852
UR  - https://doi.org/10.1142/S1402925111001532
DO  - 10.1142/S1402925111001532
ID  - Bagnoli2021
ER  -