How the Mutational-Selection Interplay Organizes the Fitness Landscape
- 10.1142/S1402925111001532How to use a DOI?
- Fitness; natural selection; mutation; quasi species
Fundamental questions posed in classical genetics since early 20th century are still fundamental in today post genomic age. What has changed is the availability of huge amount of molecular genetics information on a broad spectrum of species and a more powerful and rich methodological approach, particularly that one based on statistical mechanics and dynamical system theory which is providing unprecedented prediction power. Here we focus on the behavior of basic life forms such as bacteria and viruses which have small genomes and short generation times. We show that central issues of the evolutionary theory, i.e. how genotype, phenotype and fitness are related, the effect of positive and negative natural selection, the specie formation could be described by simple models which allow predictions and validation using experimental data.
- © 2011 The Authors. Published by Atlantis Press and Taylor & Francis
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Franco Bagnoli AU - Píetro Lió PY - 2021 DA - 2021/01/07 TI - How the Mutational-Selection Interplay Organizes the Fitness Landscape JO - Journal of Nonlinear Mathematical Physics SP - 265 EP - 286 VL - 18 IS - Supplement 2 SN - 1776-0852 UR - https://doi.org/10.1142/S1402925111001532 DO - 10.1142/S1402925111001532 ID - Bagnoli2021 ER -