Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application
These authors contributed equally to this work.
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- Mesenchymal stem cells, therapy, sepsis
Sepsis is a life-threatening organ dysfunction caused by a deregulated host response to infection, and is the most common cause of death in the intensive care unit. Although the pathogenesis of sepsis has made substantial progress, the current clinical treatment of sepsis is basically symptomatic treatment, including the infusion of antibiotics and catecholamine, and no effective conventional treatment has been found. The focus of research is Mesenchymal Stem Cells (MSCs). It can be a novel therapeutic tool to treat sepsis. MSCs have the characteristics of anti-inflammatory, antibacterial, anti-apoptosis, regulating immunity, and tissue and organ repair. The pre-clinical research and a few clinical phase I studies are reviewed to review the current cell therapy for sepsis. Using the characteristics of MSCs provides new ideas for the treatment of sepsis.
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- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Junyi Sun AU - Xianfei Ding AU - Tongwen Sun PY - 2021 DA - 2021/06/29 TI - Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application JO - Intensive Care Research SP - 2 EP - 10 VL - 1 IS - 1-2 SN - 2666-9862 UR - https://doi.org/10.2991/icres.k.210622.001 DO - https://doi.org/10.2991/icres.k.210622.001 ID - Sun2021 ER -