Intensive Care Research

Volume 1, Issue 1-2, June 2021, Pages 2 - 10

Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application

Authors
Junyi Sun, Xianfei Ding, Tongwen Sun*
General ICU, The First Affiliated Hospital of Zhengzhou University, Henan Key Laboratory of Critical Care Medicine, Zhengzhou Key Laboratory of Sepsis, Henan Engineering Research Center for Critical Care Medicine, Zhengzhou 450052, China

These authors contributed equally to this work.

*Corresponding author. Email: suntongwen@163.com
Corresponding Author
Tongwen Sun
Received 6 February 2021, Accepted 3 June 2021, Available Online 29 June 2021.
DOI
https://doi.org/10.2991/icres.k.210622.001How to use a DOI?
Keywords
Mesenchymal stem cells, therapy, sepsis
Abstract

Sepsis is a life-threatening organ dysfunction caused by a deregulated host response to infection, and is the most common cause of death in the intensive care unit. Although the pathogenesis of sepsis has made substantial progress, the current clinical treatment of sepsis is basically symptomatic treatment, including the infusion of antibiotics and catecholamine, and no effective conventional treatment has been found. The focus of research is Mesenchymal Stem Cells (MSCs). It can be a novel therapeutic tool to treat sepsis. MSCs have the characteristics of anti-inflammatory, antibacterial, anti-apoptosis, regulating immunity, and tissue and organ repair. The pre-clinical research and a few clinical phase I studies are reviewed to review the current cell therapy for sepsis. Using the characteristics of MSCs provides new ideas for the treatment of sepsis.

Chinese Abstract

脓毒症是一种危及生命的器官功能障碍,由宿主对感染的反应失调引起,也是重症监护病房(ICU)最常见的死亡原因。虽然脓毒症的发病机制已取得实质性进展,但目前临床上针对脓毒症的治疗基本上都是对症治疗,包括抗生素和儿茶酚胺的输注,尚未发现有效的常规治疗方法。当前研究的重点是间充质干细胞(MSCs),为脓毒症的治疗提供了一种新的治疗手段。MSCs具有抗炎、抗菌、抗凋亡、调节免疫、组织器官修复等作用。本文总结了目前干细胞治疗脓毒症的临床前研究和一些临床Ⅰ期研究,探讨MSCs的细胞特性为脓毒症的治疗提供的新的思路。

Copyright
© 2021 First Affiliated Hospital of Zhengzhou University. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Intensive Care Research
Volume-Issue
1 - 1-2
Pages
2 - 10
Publication Date
2021/06/29
ISSN (Online)
2666-9862
DOI
https://doi.org/10.2991/icres.k.210622.001How to use a DOI?
Copyright
© 2021 First Affiliated Hospital of Zhengzhou University. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Junyi Sun
AU  - Xianfei Ding
AU  - Tongwen Sun
PY  - 2021
DA  - 2021/06/29
TI  - Mesenchymal Stem Cells in Sepsis: From Basic Research to Clinical Application
JO  - Intensive Care Research
SP  - 2
EP  - 10
VL  - 1
IS  - 1-2
SN  - 2666-9862
UR  - https://doi.org/10.2991/icres.k.210622.001
DO  - https://doi.org/10.2991/icres.k.210622.001
ID  - Sun2021
ER  -