Glucocorticoids Use and Post-Hospitalization Outcomes among Patients with Coronavirus Disease 2019: A Systematic Review of Observational Studies with Meta-Analysis
- DOI
- 10.2991/dsahmj.k.211028.001How to use a DOI?
- Keywords
- COVID-19; glucocorticoids; mortality; meta-analysis
- Abstract
Background: A systematic review with meta-analysis was conducted to assess the association of glucocorticoids use with the likelihood of all-cause mortality in cases with Coronavirus Disease 2019 (COVID-19).
Methods: Databases and cross-referencing were searched for observational studies about patients with COVID-19 who had a definite outcome (recovered/discharged or death). The outcome of interest was all-cause mortality, and the main exposure was receiving glucocorticoids after hospital admission. Results were pooled from selected studies by random-effects mode. Heterogeneity was examined using Q and I2 statistic, and a potential small-study effect was assessed through testing of the funnel plot asymmetry. Eighteen observational studies involving 10,039 patients with COVID-19 were pooled for final meta-analyses.
Results: Overall, the pooled results demonstrated that the association of glucocorticoids use with the risk of mortality was not statistically significant among individuals with COVID-19 (odds ratio = 1.39; 95% confidence interval, 0.83–2.3299) with significant heterogeneity and substantial inconsistency (Q = 292.24, p < 0.01, I2 = 94%). Subgroup analysis showed non-significant results, except for studies that reported using methylprednisolone.
Conclusion: The risk of death among COVID-19 patients may be not associated with exposure to glucocorticoids after hospitalization, except for methylprednisolone, which may be decrease the risk of death. However, these findings should be interpreted with caution because of substantial inconsistency across studies.
- Copyright
- © 2021 Dr. Sulaiman Al Habib Medical Group. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
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TY - JOUR AU - Ebtihag O. Alenzi AU - Hanaa O. Alenizi PY - 2021 DA - 2021/11/05 TI - Glucocorticoids Use and Post-Hospitalization Outcomes among Patients with Coronavirus Disease 2019: A Systematic Review of Observational Studies with Meta-Analysis JO - Dr. Sulaiman Al Habib Medical Journal SP - 133 EP - 139 VL - 3 IS - 4 SN - 2590-3349 UR - https://doi.org/10.2991/dsahmj.k.211028.001 DO - 10.2991/dsahmj.k.211028.001 ID - Alenzi2021 ER -