Clinical Hematology International

Volume 1, Issue 3, September 2019

1. Management of Sickle Cell Intrahepatic Cholestasis: An Argument in Favor of Automated Exchange Transfusion

Brian D. Adkins, Bipin N. Savani, Garrett S. Booth
Pages: 127 - 133
Sickle cell disease patients are commonly treated at transfusion medicine services, and understanding of the hepatic manifestations of the disease is key for optimal management, specifically, in individuals presenting with sickle cell intrahepatic cholestasis (SCIC). SCIC represents a rare, severe hepatic...
Review Article

2. Natural Killer Cell-Mediated Cellular Therapy of Hematological Malignancies

Ugur Sahin, Meral Beksac
Pages: 134 - 141
Our understanding on the mechanisms of graft versus tumor/leukemia (GvT/GvL) and graft versus host (GvH) effects has tremendously evolved within the past decades. During the search for a mechanism that augments GvT/GvL without increasing GvH effects, natural killer (NK) cells have clearly attracted attention....
Review Article

3. Lower Genital Tract Precancer and Cancer in Hematopoietic Cell Transplant Survivors and the Role of HPV: A Systematic Review and Future Perspectives

Mohammad Shahrukh Tanweer, Mahmoud Aljurf, Bipin N. Savani, Perviz K. Iqbal, Shahrukh Hashmi
Pages: 142 - 153
Female recipients of hematopoietic cell transplant (HCT) may develop lower genital tract (LGT) dysplasia or new malignancies. A comprehensive systematic review to delineate the occurrence and risk factors for post-HCT LGT precancer and cancer in women was conducted via electronic search of the Cochrane...
Review Article

4. Allogeneic Stem Cell Transplantation with CD34+ Cell Selection

Elisa Roldan, Miguel Angel Perales, Pere Barba
Pages: 154 - 160
The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft-versus-host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising...
Research Article

5. Robust Selections of Various Hematopoietic Cell Fractions on the CliniMACS Plus Instrument

Sandhya R. Panch, Opal L. Reddy, Katherine Li, Thejaswi Bikkani, Anusha Rao, Swathi Yarlagadda, Steven Highfill, Daniel Fowler, Richard W. Childs, Minocher Battiwalla, John Barrett, Andre Larochelle, Crystal Mackall, Nirali Shah, David F. Stroncek
Pages: 161 - 167
Cell separation technologies play a vital role in the graft engineering of hematopoietic cellular fractions, particularly with the rapid expansion of the field of cellular therapeutics. The CliniMACS Plus Instrument (Miltenyi Biotec) utilizes immunomagnetic techniques to isolate hematopoietic progenitor...
Research Article

6. The Impact of First Complete Remission by PET-CT and Time to Next Treatment on Survival of Follicular Lymphoma Patients

Tran-Der Tan, Lun-Wei Chiou, Mau-Ching Wu, Jia-Shing Wu, Ming-Yuan Lee, Yu-Yi Huang, Shing-Su Chen
Pages: 168 - 172
We retrospectively analyzed the impact of initial positron emission tomography and computed tomography (PET-CT) complete remission (CR) and time to next treatment (TTNT) on patient outcome in follicular lymphoma. Between 2002 and 2014, 150 patients could be evaluated for treatment response and long-term...