Allogeneic Stem Cell Transplantation with CD34+ Cell Selection
- 10.2991/chi.d.190613.001How to use a DOI?
- Allogeneic transplant; Graft-versus-host disease; T cell depletion; CD34+ cell selection; Graft-versus-host disease-free and relapse-free survival (GRFS)
The success of allogeneic stem cell transplant is hampered by the development of acute and chronic graft-versus-host disease (GvHD) which has direct impact on treatment-related mortality and morbidity. As a result, T cell depletion through positive selection of CD34+ cells has emerged as a promising strategy to reduce acute and chronic GvHD in these patients.
In this review, we summarize the main characteristics of allogeneic stem cell transplant with CD34+ cell selection including risks of graft failure, GvHD, infection, organ toxicity, and long-term survival. Moreover, we highlight future strategies to improve the results of this platform and to consolidate its use in clinical practice.
- © 2019 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Elisa Roldan AU - Miguel Angel Perales AU - Pere Barba PY - 2019 DA - 2019/09/01 TI - Allogeneic Stem Cell Transplantation with CD34+ Cell Selection JO - Clinical Hematology International SP - 154 EP - 160 VL - 1 IS - 3 SN - 2590-0048 UR - https://doi.org/10.2991/chi.d.190613.001 DO - 10.2991/chi.d.190613.001 ID - Roldan2019 ER -