Clinical Hematology International

Volume 3, Issue 3, September 2021, Pages 83 - 95

History and Development of Autologous Stem Cell Transplantation for Acute Myeloid Leukemia

Authors
Norbert Claude Gorin*, ORCID
Department of Hematology and Cell Therapy, and EBMT Global Committee, Hopital Saint-Antoine APHP, Paris Sorbonne University, Paris, France
Corresponding Author
Norbert Claude Gorin
Received 19 April 2021, Accepted 3 June 2021, Available Online 15 July 2021.
DOI
https://doi.org/10.2991/chi.k.210703.002How to use a DOI?
Keywords
Autologous stem cell transplantation; acute myelogenous leukemia; cryopreservation; review; history
Abstract

This review describes the development of cryopreservation, the birth of autologous stem cell transplantation (ASCT) and its past and present use to consolidate adult patients with acute myelogenous leukemia (AML). It summarizes the first autografts in patients in relapse, the experience of autografting in complete remission (CR), using bone marrow unpurged or purged in vitro with cyclophosphamide-derivatives, and the important shift to peripheral blood stem cells. The review also discusses the results of recent studies in favor of the use of ASCT to consolidate good- and intermediate-risk patients who reach CR with no detectable minimal residual disease, and those which support the inclusion of maintenance therapy post autograft with hypomethylating agents, anti-BCL-2, and, possibly, in the future, anti AML chimeric antigen receptor-T cells. Carefully applied to well-selected patients, ASCT may regain interest, because of its simplicity, its reduced toxicity, lower non-relapse mortality and better quality of life.

Copyright
© 2021 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Clinical Hematology International
Volume-Issue
3 - 3
Pages
83 - 95
Publication Date
2021/07/15
ISSN (Online)
2590-0048
DOI
https://doi.org/10.2991/chi.k.210703.002How to use a DOI?
Copyright
© 2021 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Norbert Claude Gorin
PY  - 2021
DA  - 2021/07/15
TI  - History and Development of Autologous Stem Cell Transplantation for Acute Myeloid Leukemia
JO  - Clinical Hematology International
SP  - 83
EP  - 95
VL  - 3
IS  - 3
SN  - 2590-0048
UR  - https://doi.org/10.2991/chi.k.210703.002
DO  - https://doi.org/10.2991/chi.k.210703.002
ID  - Gorin2021
ER  -