P.04 A Transfer-Function-Free Technique for the Non-Invasive Estimation of Central Arterial Pressure
- DOI
- 10.2991/artres.k.201209.018How to use a DOI?
- Keywords
- Non-invasive pressure estimation
- Abstract
Background: Central aortic pressure (CAP) is important for the determination of the cardiovascular risk. Transfer function (TF)-based techniques allow for estimating CAP non-invasively from pressure waveforms acquired distally in the circulation. However, TF-based CAP might preserve the high frequencies of the distal waveform [1]. Therefore, we propose a new method where CAP is estimated from local direct non-invasive measurements of diameter (D) and blood velocity (U) waveforms.
Methods: Aortic root D and U were measured using an ultrasound scanner (GE, Vivid E95) in 10 healthy volunteers (46 ± 15 years, 5 men), and used to determine local wave speed (PWV) using the lnDU-loop method [2]. Brachial systolic (Ps) and diastolic blood pressure (Pd), as well as central Ps, were also estimated using a sphygmomanometer (Uscom, BPPLUS-R7). CAP was determined as:
, where, and blood density = 1060 kg/m3.
Results: Mean brachial Ps and Pd were 124.1 ± 9.5 and 77.9 ± 5.4 mmHg, respectively. Mean PWV was 3.07 ± 0.71 m/s, leading to = 1.00 ± 0.46. The average calculated Ps was only –0.4% lower than TF-Ps (116.4 ± 11.2 vs. 116.9 ± 8.9, mmHg). Estimated calculated aortic and measured brachial mean pressure were almost identical with a difference of 0.01% (97.8 ± 6.9 vs. 97.8 ± 6.5, mmHg).
Discussion: This proof-of-concept study shows that the CAP waveform can be estimated non-invasively from measurements of brachial Pd, and aortic D and U obtained using equipment available in almost every cardiovascular clinic. Further studies are warranted to establish the full utility of the new technique.
FigureA: typical example of aortic D converted into CAP. B: Bland-Altman comparison between calculated and TF Ps.
- Copyright
- © 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Alessandro Giudici AU - Ioana Cretu AU - Madalina Negoita AU - Ian B Wilkinson AU - Ashraf W Khir PY - 2020 DA - 2020/12/31 TI - P.04 A Transfer-Function-Free Technique for the Non-Invasive Estimation of Central Arterial Pressure JO - Artery Research SP - S24 EP - S24 VL - 26 IS - Supplement 1 SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.201209.018 DO - 10.2991/artres.k.201209.018 ID - Giudici2020 ER -