Artery Research

In Press, Corrected Proof, Available Online: 8 December 2020

Factors Associated with Cardio Ankle Vascular Index (CAVI) and its Mathematically Corrected Formula (CAVI0) in Community Dwelling Individuals

Authors
Li-Ju Lin1, Nan-Chen Hsieh2, Shu-Fang Vivienne Wu3, Tan-Hsu Tan4, ORCID, Azadeh Alizargar4, Chyi-Huey Bai5, Javad Alizargar6, *, ORCID
1Department of Geronological Health Care, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan
2Department of Information Management, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan
3College of Nursing, School of Nursing, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan
4Department of Electrical Engineering, National Taipei University of Technology, Taipei City 10608, Taiwan
5Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan
6Research Center for Healthcare Industry Innovation, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan
*Corresponding author. Email: jaz.tmu@gmail.com
Corresponding Author
Javad Alizargar
Received 26 May 2020, Accepted 9 November 2020, Available Online 8 December 2020.
DOI
https://doi.org/10.2991/artres.k.201124.002How to use a DOI?
Keywords
Atherosclerosis, cardiovascular diseases, cardio ankle vascular index, ankle brachial index, hypertension, atherosclerosis, risk factor
Abstract

Cardio Ankle Vascular Index (CAVI) and mathematically corrected formula derived from it (CAVI0) are indices for arterial stiffness and atherosclerosis. Role of different atherosclerotic risk factors on CAVI and CAVI0 is not clear in the community dwelling individuals. This study aims to evaluate the association of different Cardiovascular Disease (CVD) risk factors on CAVI and CAVI0. Participants from a prospective cohort study have been recruited for CAVI measurement. Known risk factors for atherosclerosis were assessed in the individuals. CAVI and CAVI0 is highly correlated (Pearson’s r = 0.95 and p < 0.001). Further correlation analysis of the study variables with CAVI shows that CAVI is significantly correlated with age, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Blood Pressure (MBP). CAVI0 is also significantly correlated with age, SBP and MBP. CAVI0 is not correlated with DBP (Pearson’s r = 0.05 and p = 0.46). Among laboratory tests, CAVI and CAVI0 are correlated with Blood Urea Nitrogen (BUN) (r = 0.20, p = 0.009 and r = 0.22, p = 0.004 respectively) and also with HBA1c (r = 0.21, p = 0.006 and r = 0.25, p = 0.001 respectively). Multivariate analysis showed that only age is independent determinant of CAVI and CAVI0. As SBP and DBP are not independently associated with CAVI and CAVI0, these indices could be considered reliable in differentiating people with high risks of CVD, as it is not dependent on other risk factors. As CAVI0 is not correlated with DBP, when evaluating the results of CAVI0, we should consider that this index maybe not be reflective of DBP in the patient.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Publication Date
2020/12
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.2991/artres.k.201124.002How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Li-Ju Lin
AU  - Nan-Chen Hsieh
AU  - Shu-Fang Vivienne Wu
AU  - Tan-Hsu Tan
AU  - Azadeh Alizargar
AU  - Chyi-Huey Bai
AU  - Javad Alizargar
PY  - 2020
DA  - 2020/12
TI  - Factors Associated with Cardio Ankle Vascular Index (CAVI) and its Mathematically Corrected Formula (CAVI₀) in Community Dwelling Individuals
JO  - Artery Research
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201124.002
DO  - https://doi.org/10.2991/artres.k.201124.002
ID  - Lin2020
ER  -