Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol
- https://doi.org/10.2991/artres.k.201124.001How to use a DOI?
- COVID-19, coronavirus, inflammation, vascular ageing, arterial stiffness
In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study — the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable.
- © 2020 The Authors. Publishing services by Atlantis Press International B.V.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Rosa Maria Bruno AU - Bart Spronck AU - Bernhard Hametner AU - Alun Hughes AU - Patrick Lacolley AU - Christopher C. Mayer AU - Maria Lorenza Muiesan AU - Chakravarthi Rajkumar AU - Dimitrios Terentes-Printzios AU - Thomas Weber AU - Tine Willum Hansen AU - Pierre Boutouyrie AU - on behalf of the ARTERY Society PY - 2020 DA - 2020/12 TI - Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol JO - Artery Research SN - 1876-4401 UR - https://doi.org/10.2991/artres.k.201124.001 DO - https://doi.org/10.2991/artres.k.201124.001 ID - Bruno2020 ER -