Artery Research

In Press, Corrected Proof, Available Online: 8 December 2020

Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol

Authors
Rosa Maria Bruno1, *, ORCID, Bart Spronck2, 3, ORCID, Bernhard Hametner4, ORCID, Alun Hughes5, ORCID, Patrick Lacolley6, ORCID, Christopher C. Mayer4, ORCID, Maria Lorenza Muiesan7, ORCID, Chakravarthi Rajkumar8, ORCID, Dimitrios Terentes-Printzios9, ORCID, Thomas Weber10, ORCID, Tine Willum Hansen11, ORCID, Pierre Boutouyrie1, ORCID, on behalf of the ARTERY Society
1INSERM U970 Team 7, Paris Cardiovascular Research Centre - PARCC, University Paris Descartes, AP-HP, Pharmacology Unit, Hôpital Européen Georges Pompidou, 56 Rue Leblanc, Paris 75015, France
2Department of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands
3Department of Biomedical Engineering, School of Engineering & Applied Science, Yale University, New Haven, CT, USA
4Center for Health & Bioresources, Biomedical Systems, AIT Austrian Institute of Technology GmbH, Vienna, Austria
5MRC unit for Lifelong Health and Ageing, Institute of Cardiovascular Science, University College London, UK
6Faculty of Medicine, Lorraine University, Inserm, DCAC, Nancy, France
7Department of Clinical & Experimental Sciences, University, of Brescia-Medicina 2, ASST Spedali Civili Brescia, Brescia, Italy
8Department of Medicine, Brighton & Sussex Medical School, Brighton, UK
9First Cardiology Department, Athens Medical School, Hippokration Hospital, Athens, Greece
10Cardiology Department, Klinikum Wels-Grieskirchen, Wels, Austria
11Steno Diabetes Center Copenhagen, Clinical Research Department, Denmark
*Corresponding author. Email: rosa-maria.bruno@inserm.fr
Corresponding Author
Rosa Maria Bruno
Received 15 August 2020, Accepted 16 November 2020, Available Online 8 December 2020.
DOI
https://doi.org/10.2991/artres.k.201124.001How to use a DOI?
Keywords
COVID-19, coronavirus, inflammation, vascular ageing, arterial stiffness
Abstract

In December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study — the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable.

Copyright
© 2020 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Artery Research
Publication Date
2020/12
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
https://doi.org/10.2991/artres.k.201124.001How to use a DOI?
Copyright
© 2020 The Authors. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Bart Spronck
AU  - Bernhard Hametner
AU  - Alun Hughes
AU  - Patrick Lacolley
AU  - Christopher C. Mayer
AU  - Maria Lorenza Muiesan
AU  - Chakravarthi Rajkumar
AU  - Dimitrios Terentes-Printzios
AU  - Thomas Weber
AU  - Tine Willum Hansen
AU  - Pierre Boutouyrie
AU  - on behalf of the ARTERY Society
PY  - 2020
DA  - 2020/12
TI  - Covid-19 Effects on ARTErial StIffness and Vascular AgeiNg: CARTESIAN Study Rationale and Protocol
JO  - Artery Research
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.201124.001
DO  - https://doi.org/10.2991/artres.k.201124.001
ID  - Bruno2020
ER  -