Artery Research

Volume 7, Issue 3-4, September 2013, Pages 137 - 137

P4.06 ARTERIAL STIFFNESS CORRELATES WITH VITAMIN D DEFICIENCY IN HYPERTENSIVE PATIENTS WITH STAGE 3 CHRONIC KIDNEY DISEASE INDEPENDENTLY OF BLOOD PRESSURE

Authors
Rodilla Sala Enrique1, 2, Costa Muñoz José Antonio1, Taverner Marta1, Pascual Izuel José María1, 3, Malek Marín Tamara1
1Unidad HTA y Riesgo Vascular, Servicio Medicina Interna, Hospital de Sagunto, Sagunto, Spain
2Facyultad de Ciencias de la Salund, Universidad Cardenal Herrera, Castellón, Castellón, Spain
3Facultad de Medicina, Universidad de Valencia, Valencia, Spain
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.125How to use a DOI?
Abstract

Objectives: To assess the prevalence of vitamin D deficiency and hyperparathyroidism as well as their relationship to blood pressure and arterial stiffness in hypertensive patients with stage 3 chronic kidney disease (CKD).

Methods: Cross-sectional study that included 134 treated hypertensives (76 women, 56,7%) with stage 3 CKD (eGFR 49,2 ml/min, SD±8) without previous vitamin D supplementation treatment. Standard clinical care was performed including ECG, microalbuminuria and usual laboratory parameters. Arterial stiffness was measured by brachial oscillometry with the validated Mobil-O-Graph® device. Normal values for vitamin D and PTH were set as 30 ng/ml and 65 pg/ml, respectively.

Results: The mean age was 73,0 years (SD±10) with office BP of 131/75 mmHg (SD±17/11). The prevalence of vitamin D deficiency was 89% (mean: 19 ng/ml (SD±10)), secondary hyperparathytoidism was observed in 49% of patients (mean: 70,5 pg/ml (SD±10)), 84 (62,7%) patients had a pulse wave velocity (PWV) over 10 m/sec (mean 10,7 m/sec, (SD±1,8). In bivariate analysis PWV correlated best with age (r=930;p<0.0001), followed by SBP (r=345;p<0.0001), vitamin D (r=310;p<0.0001), PTH, calcium, fosforous and ventricular mass (CORNELL). In multiple lineal regression analysis, only age, SBP and vitamin D remained significantly associated with arterial stiffness. In logistic regression with presence /absence of PWV ≥ 10 m/sec as dependent variable, male gender, age, elevated SBP and vitamin D categorized in tertiles were significantly related to increased PWV.

Conclusions: In hypertensive patients with stage 3 CKD vitamin D deficiency is associated to increased PWV independently of blood pressure, gender and age.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
137 - 137
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.125How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Rodilla Sala Enrique
AU  - Costa Muñoz José Antonio
AU  - Taverner Marta
AU  - Pascual Izuel José María
AU  - Malek Marín Tamara
PY  - 2013
DA  - 2013/11/11
TI  - P4.06 ARTERIAL STIFFNESS CORRELATES WITH VITAMIN D DEFICIENCY IN HYPERTENSIVE PATIENTS WITH STAGE 3 CHRONIC KIDNEY DISEASE INDEPENDENTLY OF BLOOD PRESSURE
JO  - Artery Research
SP  - 137
EP  - 137
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.125
DO  - 10.1016/j.artres.2013.10.125
ID  - SalaEnrique2013
ER  -