Artery Research

Volume 7, Issue 3-4, September 2013, Pages 131 - 132

P3.20 CLINICAL SIGNIFICANCE OF AMBULATORY ARTERIAL STIFFNESS INDEX (AASI) IN YOUNG STAGE 1 HYPERTENSIVE’ S

Authors
F. Saladini1, E. Benetti1, C. Fania1, L. Mos2, P. Ballerini3, E. Cozzutti3, G. Garavelli4, S. Cozzio5, E. Casiglia1, P. Palatini1
1University of Padova, Padova, Italy
2Town Hospital, San Daniele del Friuli, Italy
3Town Hospital, Vittorio Veneto, Italy
4Town Hospital, Cremona, Italy
5Town Hospital, Trento, Italy
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.107How to use a DOI?
Abstract

Objective: The aim of the study was to examine the relationship between AASI and age in a cohort of stage I hypertensives < 50 years of age and to investigate its predictive capacity for future established hypertension.

Methods: We studied 1157 subjects from the HARVEST study (mean follow-up 5.9 years). AASI and 24-h pulse pressure (PP) were calculated from 24-h ambulatory recordings. The predictive value of AASI for incident hypertension was evaluated with Cox regression analysis adjusting for age, sex, mean 24-h blood pressure (BP).

Results: Baseline office BP was 145.5±10.4/93.6±5.6 mmHg, 24-h PP was 49.6±11.2 mmHg, AASI was 0.56±0.2. AASI was correlated with 24-h PP (r=0.41, p<0.0001), and showed a U-shaped correlation with age. In our population age was inversely correlated with 24-h PP (r=−0.32, p<0.0001). The highest sex-adjusted AASI values were found in the two bottom and the top age deciles (mean±SEM, 0.62±0.02, 0.61±0.02, and 0.60±0.02, respectively). During follow-up 55.7% of the subjects developed established hypertension needing pharmacological treatment. In a multivariate Cox analysis, AASI showed a negative predictive value for the development of future hypertension (p<0.001). Participants in the middle AASI tertile (H.R. and 95%CI: 0.81, 0.67–0.97, p=0.03) and top tertile (0.71, 0.57–0.87, p=0.001) had a lower risk of developing hypertension compared to subjects in the bottom tertile.

Conclusions: AASI shows a U-shaped relationship with age in a population of young-to-middle-age hypertensives and it may be even a predictor of better outcome. So, the clinical significance of AASI in hypertension appears to be heavily dependent on age.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
131 - 132
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.107How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - F. Saladini
AU  - E. Benetti
AU  - C. Fania
AU  - L. Mos
AU  - P. Ballerini
AU  - E. Cozzutti
AU  - G. Garavelli
AU  - S. Cozzio
AU  - E. Casiglia
AU  - P. Palatini
PY  - 2013
DA  - 2013/11/11
TI  - P3.20 CLINICAL SIGNIFICANCE OF AMBULATORY ARTERIAL STIFFNESS INDEX (AASI) IN YOUNG STAGE 1 HYPERTENSIVE’ S
JO  - Artery Research
SP  - 131
EP  - 132
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.107
DO  - 10.1016/j.artres.2013.10.107
ID  - Saladini2013
ER  -