P3.19 AORTIC PULSE PRESSURE BETTER PREDICTS INCREASES ARTERIAL STIFFNESS COMPARED TO BRACHIAL AND AMBULATORY MEASUREMENTS

DOI

10.1016/j.artres.2013.10.106How to use a DOI?

Abstract

Objectives: Hypertension is associated with increased arterial stiffness, which is an independent predictor of cardiovascular risk. Aortic systolic blood pressure (SBP) and/or pulse pressure (PP) better predicts cardiovascular events than peripheral blood pressure. The present study compared the discriminative ability for increased arterial stiffness of aortic BP with ambulatory peripheral BP, with reference to office brachial SBP or PP in never treated hypertensives.

Methods: We enrolled 619 consecutive essential hypertensives (mean age 52.2±12.0 years, 325 men). Arterial stiffness was determined with carotid-femoral pulse wave velocity (PWV) using the Complior^® device. Aortic pressures were measured using the Sphygmocor® device and 24h ambulatory SBP and PP were obtained from 24h ambulatory blood pressure monitoring. We employed dichotomous outcome variable (PWV≥75th percentile [8.55 m/s]). Receiver operating characteristic (ROC) curves were generated to evaluate the ability of the pressures to discriminate subjects with and without significant arterial stiffness (PWV ≥75th percentile [8.55 m/s]).

Results: All different types of blood pressure significantly discriminated subjects with significant arterial stiffness (all p<0.001). Aortic pulse pressure had the highest area under the curve (AUC=0.741) and 24h ambulatory SBP the lowest (AUC=0.655). (Figure, Table).

Conclusions: PP is more valuable than SBP pressure in the prediction of increased arterial stiffness. Moreover, aortic PP may better predict increased arterial stiffness than brachial or ambulatory BP measurements.

Variable	AUC	95% CI
Aortic pulse pressure	0.741*†‡	0.696–0.786
Aortic systolic blood pressure	0.717*†	0.672–0.762
Brachial pulse pressure	0.710*	0.664–0.756
Brachial systolic blood pressure	0.681*¶	0.634–0.727
24h ambulatory pulse pressure	0.705*†	0.657–0.753
24h ambulatory systolic blood pressure	0.655*#¶§	0.605–0.705

*

P<0.001 compared to the null hypothesis that the AUC is 0.5 and the examined variables cannot discriminate subjects with low or high pulse wave velocity values.

†

P<0.05 compared to 24h ambulatory systolic blood pressure

#

P<0.05 compared to 24h ambulatory pulse pressure.

‡

P<0.05 compared to brachial systolic blood pressure.

¶

P<0.05 compared to aortic pulse pressure.

§

P<0.05 compared to aortic systolic blood pressure.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - D. Terentes-Printzios
AU  - C. Vlachopoulos
AU  - N. Ioakeimidis
AU  - K. Aznaouridis
AU  - P. Pietri
AU  - M. Abdelrassoul
AU  - P. Xaplanteris
AU  - A. Aggelakas
AU  - C. Stefanadis
PY  - 2013
DA  - 2013/11/11
TI  - P3.19 AORTIC PULSE PRESSURE BETTER PREDICTS INCREASES ARTERIAL STIFFNESS COMPARED TO BRACHIAL AND AMBULATORY MEASUREMENTS
JO  - Artery Research
SP  - 131
EP  - 131
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.106
DO  - 10.1016/j.artres.2013.10.106
ID  - Terentes-Printzios2013
ER  -