P3.20 CLINICAL SIGNIFICANCE OF AMBULATORY ARTERIAL STIFFNESS INDEX (AASI) IN YOUNG STAGE 1 HYPERTENSIVE’ S

F. Saladini; E. Benetti; C. Fania; L. Mos; P. Ballerini; E. Cozzutti; G. Garavelli; S. Cozzio; E. Casiglia; P. Palatini

doi:10.1016/j.artres.2013.10.107

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Volume 7, Issue 3-4, September 2013, Pages 131 - 132

P3.20 CLINICAL SIGNIFICANCE OF AMBULATORY ARTERIAL STIFFNESS INDEX (AASI) IN YOUNG STAGE 1 HYPERTENSIVE’ S

Authors

F. Saladini¹, E. Benetti¹, C. Fania¹, L. Mos², P. Ballerini³, E. Cozzutti³, G. Garavelli⁴, S. Cozzio⁵, E. Casiglia¹, P. Palatini¹

¹University of Padova, Padova, Italy

²Town Hospital, San Daniele del Friuli, Italy

³Town Hospital, Vittorio Veneto, Italy

⁴Town Hospital, Cremona, Italy

⁵Town Hospital, Trento, Italy

Available Online 11 November 2013.

DOI: 10.1016/j.artres.2013.10.107 How to use a DOI?
Abstract: Objective: The aim of the study was to examine the relationship between AASI and age in a cohort of stage I hypertensives < 50 years of age and to investigate its predictive capacity for future established hypertension.

Methods: We studied 1157 subjects from the HARVEST study (mean follow-up 5.9 years). AASI and 24-h pulse pressure (PP) were calculated from 24-h ambulatory recordings. The predictive value of AASI for incident hypertension was evaluated with Cox regression analysis adjusting for age, sex, mean 24-h blood pressure (BP).

Results: Baseline office BP was 145.5±10.4/93.6±5.6 mmHg, 24-h PP was 49.6±11.2 mmHg, AASI was 0.56±0.2. AASI was correlated with 24-h PP (r=0.41, p<0.0001), and showed a U-shaped correlation with age. In our population age was inversely correlated with 24-h PP (r=−0.32, p<0.0001). The highest sex-adjusted AASI values were found in the two bottom and the top age deciles (mean±SEM, 0.62±0.02, 0.61±0.02, and 0.60±0.02, respectively). During follow-up 55.7% of the subjects developed established hypertension needing pharmacological treatment. In a multivariate Cox analysis, AASI showed a negative predictive value for the development of future hypertension (p<0.001). Participants in the middle AASI tertile (H.R. and 95%CI: 0.81, 0.67–0.97, p=0.03) and top tertile (0.71, 0.57–0.87, p=0.001) had a lower risk of developing hypertension compared to subjects in the bottom tertile.

Conclusions: AASI shows a U-shaped relationship with age in a population of young-to-middle-age hypertensives and it may be even a predictor of better outcome. So, the clinical significance of AASI in hypertension appears to be heavily dependent on age.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 131 - 132
Publication Date: 2013/11/11
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.10.107 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - F. Saladini
AU  - E. Benetti
AU  - C. Fania
AU  - L. Mos
AU  - P. Ballerini
AU  - E. Cozzutti
AU  - G. Garavelli
AU  - S. Cozzio
AU  - E. Casiglia
AU  - P. Palatini
PY  - 2013
DA  - 2013/11/11
TI  - P3.20 CLINICAL SIGNIFICANCE OF AMBULATORY ARTERIAL STIFFNESS INDEX (AASI) IN YOUNG STAGE 1 HYPERTENSIVE’ S
JO  - Artery Research
SP  - 131
EP  - 132
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.107
DO  - 10.1016/j.artres.2013.10.107
ID  - Saladini2013
ER  -

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