Artery Research

Volume 7, Issue 3-4, September 2013, Pages 124 - 124

P2.19 ASSESSMENT OF AORTIC PULSE WAVE VELOCITY BY ULTRASOUND: A FEASIBILITY STUDY IN MICE

Authors
N. Di Lascio1, F. Stea1, 2, C. Kusmic1, S. Cintoli3, R. Sicari1, F. Faita1
1Institute of Clinical Physiology, National Council of Research, Pisa, Italy
2Department of Internal Medicine, University of Pisa, Pisa, Italy
3Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche (CNR), Pisa, Italy
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.080How to use a DOI?
Abstract

Pulse wave velocity (PWV) is considered a surrogate marker of arterial stiffness and could be useful for characterizing cardiovascular disease progression even in mouse models. Aim of this study was to develop an image process algorithm for assessing arterial PWV in mice using ultrasound (US) images only and test it on the evaluation of age-associated differences in abdominal aorta PWV (aaPWV). US scans were obtained from six adult (7 months) and six old (19 months) wild type male mice (strain C57BL6) under gaseous anaesthesia. For each mouse, diameter and flow velocity instantaneous values were achieved from abdominal aorta B-mode and PW-Doppler images; all measurements were obtained using edge detection and contour tracking techniques. Single-beat mean diameter and velocity were calculated and time-aligned, providing the lnD-V loop. aaPWV values were obtained from the slope of the linear part of the loop (the early systolic phase), while relative distension (relD) measurements were calculated from the mean diameter signal. aaPWV values for young mice (3.5±0.52 m/s) were lower than those obtained for older ones (5.12±0.98 m/s) while relD measurements were higher in young (25%±7%) compared with older animals evaluations (15%±3%). All measurements were significantly different between the two groups (P<0.01 both). In conclusion, the proposed image processing technique well discriminate between age groups. Since it provides PWV assessment just from US images, it could represents a simply and useful system for vascular stiffness evaluation at any arterial site in the mouse, even in preclinical small animal models.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
124 - 124
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.080How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - N. Di Lascio
AU  - F. Stea
AU  - C. Kusmic
AU  - S. Cintoli
AU  - R. Sicari
AU  - F. Faita
PY  - 2013
DA  - 2013/11/11
TI  - P2.19 ASSESSMENT OF AORTIC PULSE WAVE VELOCITY BY ULTRASOUND: A FEASIBILITY STUDY IN MICE
JO  - Artery Research
SP  - 124
EP  - 124
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.080
DO  - 10.1016/j.artres.2013.10.080
ID  - DiLascio2013
ER  -