10.04 LARGE AND SMALL ARTERY STRUCTURE & STIFFNESS IN RELATION TO GLYCAEMIA AND BLOOD PRESSURE IN PRE-MENOPAUSAL WOMEN
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Introduction: Diabetes and Hypertension affect large and small artery structure and function. We investigated the relationship between large artery structure (common carotid intima-medial thickness: cIMT), function (aortic pulse wave velocity-aPWV) and structure and stiffness index of small subcutaneous arteries in a group of pre-menopausal women who had undergone an oral glucose tolerance test (OGTT) during pregnancy.
Patients and Methods: 29 pre-menopausal women (age 36.2 years, 95% CI 35.1–37.2) underwent an OGTT and under standardised conditions, assessment of aPWV and biopsy of subcutaneous fat to assess the small arterial structure and function.
Results: cIMT was related to aPWV (r=0.58, p=0.001) and media cross-sectional area of small arteries (Mcxa, r=0.43, p=0.023); the latter correlated with small artery stiffness index (saSI, r=0.34, p=0.01). After adjustment for smoking, these independent parameters influenced vascular indices:
| Multiple regression Beta (p value) | aPWV | cIMT | saSI | McxA |
|---|---|---|---|---|
| Age | 0.16 (0.046) | 0.49 (0.034) | ||
| BMI | 0.23 (0.018) | |||
| SBP | 0.16 (0.01) | |||
| Fasting glucose | −1.4 (0.03) | −0.004 (0.03) | ||
| Total cholesterol | 1.26 (0.034) | |||
| Medial thickness | ||||
| cIMT | 264.1 (0.003) | |||
| McxA | 2.42 (0.04) |
Conclusion: In young women, even without overt diabetes or hypertension, large and small vessel structure & function but not stiffness are closely related. These vascular properties are modulated by degree of current glycaemia and other cardiovascular risk factors.
Cite this article
TY - JOUR AU - M. Banerjee AU - C. Austin AU - R.A. Malik AU - J.K. Cruickshank PY - 2007 DA - 2007/08/30 TI - 10.04 LARGE AND SMALL ARTERY STRUCTURE & STIFFNESS IN RELATION TO GLYCAEMIA AND BLOOD PRESSURE IN PRE-MENOPAUSAL WOMEN JO - Artery Research SP - 52 EP - 52 VL - 1 IS - 2 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2007.07.057 DO - 10.1016/j.artres.2007.07.057 ID - Banerjee2007 ER -