Artery Research

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Volume 1, Issue 2, September 2007, Pages 55 - 55

P.012 THE ASSOCIATION BETWEEN FREE THYROXINE, AORTIC RIGIDITY AND GENETIC POLYMORPHISM OF ANGIOTENSIN II TYPE 1 RECEPTOR IN A POPULATION SAMPLE☆

Authors
O. Mayer, J. Filipovský, M. Pešta, J. Hrbková, M. Dolejšová
2nd Dept. of Internal Medicine, Charles University, Medical Faculty, Pilsen, Czech Republic
⋆

(supported by grant IGA9333-3, Ministry of Health CZ).

Available Online 30 August 2007.
DOI
10.1016/j.artres.2007.07.069How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Thyroid hormones showed direct proliferative properties on cardiovascular system also by modulating the expression of renin-angiotensin axis. The aim of our study was to establish, whether interaction between mutation of angiotensin II, type 1 receptor (AGTR1) and mild changes in free thyroxine (fT4) may influence the aortic rigidity.

Methods: 249 euthyroid subjects (m121, f128, mean age 48.03 ± 0.70) was selected from population based-study. Aortic pulse wave velocity (PWV) was measured using Sphygmocor, A1166C mutation of AGTR1 by PCR. The sample was stratified according to fT4 quintiles for optimal (2nd to 4th quintile), low-normal (1st quintile) and high-normal (5th quintile) fT4 strata.

Results: [mean±SEM; optimal vs. low-normal (p1) or high-normal (p2), *adjusted for age and gender]

fT4 strata: optimal low-normal p1 high-normal p2
A1166C mutation absent:
n 72 32 32
age 47.7 ± 1.29 49.0 ± 2.17 0.45 51.34 ± 1.91 0.10
systolic blood pressure 122.6 ± 1.72 128.4 ± 3.40 0.12 130.6 ± 3.21 0.07*
diastolic blood pressure 79.2 ± 1.06 81.4 ± 1.93 0.43* 81.5 ± 1.57 0.50*
aortic PWV [m/sec] 7.80 ± 0.24 7.87 ± 0.41 0.40* 8.06 ± 0.75 0.57*
A1166C mutat. present:
n 75 23 0.17 15 0.26
age 46.0 ± 1.31 49.6 ± 1.98 0.33* 49.4 ± 2.68 0.09*
systolic blood pressure 123.5 ± 1.82 128.7 ± 3.19 0.34* 133.5 ± 4.27 0.89*
diastolic blood pressure 79.3 ± 1.14 82.4 ± 2.50 0.88* 81.3 ± 2.85 <0.004
aortic PWV [m/sec] 7.26 ± 0.20 7.46 ± 0.42 8.63 ± 0.72

Conclusion: In our sample of general population we found, that high-normal fT4 was associated with increased aPWV, however significantly expressed only in patient with A1166C mutation of AGTR1.

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Journal
Artery Research
Volume-Issue
1 - 2
Pages
55 - 55
Publication Date
2007/08/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.07.069How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - O. Mayer
AU  - J. Filipovský
AU  - M. Pešta
AU  - J. Hrbková
AU  - M. Dolejšová
PY  - 2007
DA  - 2007/08/30
TI  - P.012 THE ASSOCIATION BETWEEN FREE THYROXINE, AORTIC RIGIDITY AND GENETIC POLYMORPHISM OF ANGIOTENSIN II TYPE 1 RECEPTOR IN A POPULATION SAMPLE☆
JO  - Artery Research
SP  - 55
EP  - 55
VL  - 1
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.07.069
DO  - 10.1016/j.artres.2007.07.069
ID  - Mayer2007
ER  -