Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation

Jun Sugawara; Christopher K. Willie; Taiki Miyazawa; Hidehiko Komine; Philip N. Ainsle; Shigehiko Ogoh

doi:10.1016/j.artres.2012.05.002

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Volume 6, Issue 3, September 2012, Pages 130 - 135

Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation

Authors

Jun Sugawara^a^{, *}, Christopher K. Willie^b, Taiki Miyazawa^c, Hidehiko Komine^a, Philip N. Ainsle^b, Shigehiko Ogoh^c

^aHuman Technology Research Institute, National Institute of Advanced Industrial, Science and Technology (AIST), 1-1-1 Higashi, Tsukuba 305-8566, Ibaraki, Japan

^bSchool of Health and Exercise Sciences, University of British Columbia Okanagan, Canada

^cDepartment of Biomedical Engineering, Toyo University, Kawagoe-Shi, Saitama, Japan

^*Corresponding author. Tel.: +81 29 861 7138; fax: +81 29 861 6660. E-mail address: jun.sugawara@aist.go.jp (J. Sugawara).

Corresponding Author

Jun Sugawara

Received 28 March 2012, Revised 8 May 2012, Accepted 14 May 2012, Available Online 7 June 2012.

DOI: 10.1016/j.artres.2012.05.002 How to use a DOI?
Keywords: Arterial compliance; Carotid-vagal baroreflex; Head-up tilt
Abstract: Stiffening of central conduit arteries –areas where the mechanoreceptors are embedded (e.g., ascending aorta and carotid artery) – is considered to be associated with the impaired baroreflex control in response to hypotensive stress. Arterial stiffness is modulated by vascular tone transiently and dynamically, however, it is unknown whether a transient change in the carotid artery stiffness influences the cardiac baroreflex response to a rapid hypotension. We measured (n = 11) carotid arterial stiffness (via concurrent applanation tonometory and ultrasound imaging) at supine rest and during 20-degree head-up tilt (HUT). To evaluate the cardiac baroreflex response, acute hypotension was evoked by releasing bilateral thigh cuffs after 3 min of suprasystolic resting ischemia at each posture; cardiac baroreflex sensitivity (e.g., change in heart rate for a given change in mean arterial pressure, ΔHR/ΔMAP) and latency (e.g., the time to peak HR response) was estimated. Carotid β-stiffness index, a measure of arterial stiffness, was reduced by 14% during HUT (P < 0.05 vs. supine position). Although cardiac baroreflex responses were unaltered, the within-group biological variability in the cardiac baroreflex sensitivity and latency from the supine to HUT was correlated with the corresponding changes in carotid arterial stiffness (r = 0.66 and r = 0.64, respectively, both P < 0.05). These findings suggest that a transient change in carotid arterial stiffness, at least in part, influences changes in the cardiac baroreflex response to a rapid hypotension.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 6 - 3
Pages: 130 - 135
Publication Date: 2012/06/07
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2012.05.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Jun Sugawara
AU  - Christopher K. Willie
AU  - Taiki Miyazawa
AU  - Hidehiko Komine
AU  - Philip N. Ainsle
AU  - Shigehiko Ogoh
PY  - 2012
DA  - 2012/06/07
TI  - Effects of transient change in carotid arterial stiffness on arterial baroreflex during mild orthostatic stimulation
JO  - Artery Research
SP  - 130
EP  - 135
VL  - 6
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.05.002
DO  - 10.1016/j.artres.2012.05.002
ID  - Sugawara2012
ER  -

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