P10.12 AORTIC STIFFNESS IS AN INDEPENDENT DETERMINANT OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN METABOLIC SYNDROME PATIENTS

L. Ryliskyte; J. Celutkiene; S. Solovjova; R. Puronaite; J. Badariene; R. Navickas; A. Laucevicius

doi:10.1016/j.artres.2014.09.215

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Volume 8, Issue 4, December 2014, Pages 160 - 160

P10.12 AORTIC STIFFNESS IS AN INDEPENDENT DETERMINANT OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN METABOLIC SYNDROME PATIENTS

Authors

L. Ryliskyte^a^{, b}, J. Celutkiene^a^{, b}, S. Solovjova^a^{, b}, R. Puronaite^a, J. Badariene^a^{, b}, R. Navickas^a^{, b}, A. Laucevicius^a^{, b}

^aVilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania

^bVilnius University, Medical Faculty, Clinic of Cardiovascular disease, Vilnius, Lithuania

Available Online 4 November 2014.

DOI: 10.1016/j.artres.2014.09.215 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Aim: Of this study was to evaluate the relationship of arterial stiffness and left ventricular diastolic dysfunction(LVDD) in metabolic syndrome(MetS) patients.

Methods: A cross-sectional study was carried among 1208 MetS subjects (aged 54±6, 65% women, 92% hypertensive). According to the heart ultrasound findings, patients were divided into three groups: with relaxation abnormalities (GR1, n=406, LV end-diastolic diameter(LVdd) 5.02±0.49cm), with pseudonormalisation (GR2, n=713, LVdd 5.09±0.5cm) and without LVDD (LVDD-, n=89, LVdd 4.95±0.43cm). Arterial stiffness parameters (carotid to femoral pulse wave velocity (cfPW) and aortic augmentation index (AIxHR75) were assessed by applanation tonometry.

Results: In comparison to LVDD- patients, LVDD+ patients were older (55±6vs 51±6), had higher cfPWV (GR1 8.9±1.66, GR2 8.77±1.57vs 7.9±1.34m/s), AIxHR75 (GR1 25.5±10.42; GR2 24.7±10.2vs 19,7±10), mean arterial pressure(MAP) (GR1 108±12.7; GR2 107.6±12.2vs 101±10mmHg), mean carotid intima-media thickness(IMTmean) (GR1 0,651±0,098; GR2 0,656 ±0,107vs. 0,619±0.09mm), heart rate (LVDD+ 66±10vs. 61±9bpm), left ventricular mass index(LVMI) (LVDD+ 109±24vs. 97,1±22g/m²), body mass index(BMI) (LVDD+ 32±5vs 30±4 kg/m², all p<0.05).

We found significant correlations between arterial stiffness and diastolic function parameters, such as ratio of early to late transmitral pulse Doppler velocities(E/A) (rcfPWV=−0.19, rAIxHR75=−0.15, p<0.05), early diastolic mitral annular velocity(E’) (rcfPWV=−0.25, rAIxHR75=−0.18, p<0.05), and E/E’ ratio (rcfPWV=0.17, rAIxHR75=0.14, p<0.05). In multiple regression analysis, gender, MAP, LVMI, heart rate and cfPWV remained significant determinants of E/E’parameter, explaining 18% of its variability(p<0.05).

Conclusion: Carotid to femoral pulse wave velocity, an index of aortic stiffness, is a significant and independent determinant of the LVDD in subjects with metabolic syndrome.

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Journal: Artery Research
Volume-Issue: 8 - 4
Pages: 160 - 160
Publication Date: 2014/11/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.09.215 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - L. Ryliskyte
AU  - J. Celutkiene
AU  - S. Solovjova
AU  - R. Puronaite
AU  - J. Badariene
AU  - R. Navickas
AU  - A. Laucevicius
PY  - 2014
DA  - 2014/11/04
TI  - P10.12 AORTIC STIFFNESS IS AN INDEPENDENT DETERMINANT OF LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN METABOLIC SYNDROME PATIENTS
JO  - Artery Research
SP  - 160
EP  - 160
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.215
DO  - 10.1016/j.artres.2014.09.215
ID  - Ryliskyte2014
ER  -

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