4.3 IMPACT OF AGE AND GENDER ON THE HAEMODYNAMIC DETERMINANTS OF BLOOD PRESSURE ACROSS THE ADULT AGE-SPAN

A. Cocks; J. Smith; J. Woodcock-Smith; K. Miles; K. Maki-Petaja; B. McDonnell; J. Cockcroft; I. Wilkinson; C. McEniery

doi:10.1016/j.artres.2014.09.071

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Volume 8, Issue 4, December 2014, Pages 127 - 127

4.3 IMPACT OF AGE AND GENDER ON THE HAEMODYNAMIC DETERMINANTS OF BLOOD PRESSURE ACROSS THE ADULT AGE-SPAN

Authors

A. Cocks^a, J. Smith^a, J. Woodcock-Smith^a, K. Miles^a, K. Maki-Petaja^a, B. McDonnell^b, J. Cockcroft^c, I. Wilkinson^a, C. McEniery^a

^aUniversity of Cambridge, Cambridge, UK

^bCardiff Metropolitan University, Cardiff, UK

^cCardiff University, Cardiff, UK

Available Online 4 November 2014.

DOI: 10.1016/j.artres.2014.09.071 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: Systolic and diastolic blood pressure (BP) oscillate around the mean arterial pressure (MAP), which is determined, physiologically, by the cardiac output (CO) and peripheral vascular resistance (PVR). Although data describing the influence of age and gender on BP are widely available, few studies have examined the normal age-related changes in CO and PVR and the impact of gender on these changes, in a sufficiently large cohort of healthy individuals.

Methods: Detailed haemodynamic data including blood pressure (BP), CO and PVR were available in 5580 individuals (2518 males), aged between 18–92 years. Data were stratified according to gender and decade of age.

Results: As expected, MAP increased progressively with age in both males and females (P<0.001 for both). PVR was significantly higher in females at all ages and increased significantly with age in both sexes (P<0.001 for both). In contrast, CO was significantly higher in males at all ages and declined significantly with age in both sexes (P<0.001 for both). The decline in CO was due to a decline in stroke volume (SV) (P<0.001 for both), since there was no effect of age on heart rate. Adjusting CO and SV for body size abolished the gender-related differences but the age-related differences remained.

Conclusion: These data indicate that the physiological determinants of blood pressure vary between genders and with ageing, supporting the need for differential approaches in understanding, and treating high BP across the adult age-span.

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Journal: Artery Research
Volume-Issue: 8 - 4
Pages: 127 - 127
Publication Date: 2014/11/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.09.071 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - A. Cocks
AU  - J. Smith
AU  - J. Woodcock-Smith
AU  - K. Miles
AU  - K. Maki-Petaja
AU  - B. McDonnell
AU  - J. Cockcroft
AU  - I. Wilkinson
AU  - C. McEniery
PY  - 2014
DA  - 2014/11/04
TI  - 4.3 IMPACT OF AGE AND GENDER ON THE HAEMODYNAMIC DETERMINANTS OF BLOOD PRESSURE ACROSS THE ADULT AGE-SPAN
JO  - Artery Research
SP  - 127
EP  - 127
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.071
DO  - 10.1016/j.artres.2014.09.071
ID  - Cocks2014
ER  -

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