4.4 THE EFFECT OF B-VITAMIN SUPPLEMENTATION ON ARTERIAL STIFFNESS IN ELDERLY

S. Van Dijk; Y. Smulders; A. Enneman; K. Swart; J. Van Wijngaarden; A. Ham; N. Van Schoor; R. Dhonukshe-Rutten; L. De Groot; P. Lips; A. Uitterlinden; H. Blom; J. Geleijnse; E. Feskens; T. Van den Meiracker; F. Mattace-Raso; N. Van der Velde

doi:10.1016/j.artres.2014.09.072

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Volume 8, Issue 4, December 2014, Pages 127 - 127

4.4 THE EFFECT OF B-VITAMIN SUPPLEMENTATION ON ARTERIAL STIFFNESS IN ELDERLY

Authors

S. Van Dijk^a, Y. Smulders^b, A. Enneman^a, K. Swart^b, J. Van Wijngaarden^c, A. Ham^a, N. Van Schoor^b, R. Dhonukshe-Rutten^c, L. De Groot^c, P. Lips^b, A. Uitterlinden^a, H. Blom^b, J. Geleijnse^c, E. Feskens^c, T. Van den Meiracker^a, F. Mattace-Raso^a, N. Van der Velde^a

^aErasmus MC, Rotterdam, The Netherlands

^bVU University Medical Center, Amsterdam, The Netherlands

^cWageningen University, Wageningen, The Netherlands

Available Online 4 November 2014.

DOI: 10.1016/j.artres.2014.09.072 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: Hyperhomocysteinemia is an important cardiovascular risk indicator in the oldest old and is also associated with elevated arterial stiffness in this age group. Several intervention trials reported a lack of benefit of B-vitamin supplementation on cardiovascular outcomes, therefore we aimed to investigate the effect of B-vitamin supplementation on arterial stiffness and cardiovascular events in hyperhomocysteinemic elderly subjects.

Methods and Results: The B-PROOF study is a double-blind randomized-controlled trial, including 2919 elderly (≥ 65 years), with hyperhomocysteinemia (12–50 μmol/l), treated with B-vitamins (500 μg vitamin B12 and 400 μg folic acid) or placebo for 2 years. In a subgroup (n = 569) the effect of B-vitamins on pulse wave velocity (PWV) was investigated. In the total B-PROOF population, incidents of cardiovascular and cerebrovascular events were determined via structured questionnaires and also blood pressure was measured. Compared to placebo, B-vitamins lowered serum homocysteine by 3.6 μmol/L (p<0.001). Analysis of covariance showed no effect of B-vitamins supplementation on PWV levels, but aortic pulse pressure was higher in the intervention than in the placebo group (49.6 mmHg vs. 47.2 mmHg; p =0.02). Furthermore, a significant reduction of cerebrovascular events in females (OR 0.33 95%CI [0.15 ; 0.71]), but not in males was observed.

Conclusions: B-vitamins supplementation in hyperhomocysteinemic elderly has no effect on PWV and caused a modest increase in aortic pressure, but also a reduction in cerebrovascular events in females. Arterial stiffness is not likely to be the underlying pathway of the negative trial outcomes.

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 8 - 4
Pages: 127 - 127
Publication Date: 2014/11/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2014.09.072 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - S. Van Dijk
AU  - Y. Smulders
AU  - A. Enneman
AU  - K. Swart
AU  - J. Van Wijngaarden
AU  - A. Ham
AU  - N. Van Schoor
AU  - R. Dhonukshe-Rutten
AU  - L. De Groot
AU  - P. Lips
AU  - A. Uitterlinden
AU  - H. Blom
AU  - J. Geleijnse
AU  - E. Feskens
AU  - T. Van den Meiracker
AU  - F. Mattace-Raso
AU  - N. Van der Velde
PY  - 2014
DA  - 2014/11/04
TI  - 4.4 THE EFFECT OF B-VITAMIN SUPPLEMENTATION ON ARTERIAL STIFFNESS IN ELDERLY
JO  - Artery Research
SP  - 127
EP  - 127
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.072
DO  - 10.1016/j.artres.2014.09.072
ID  - VanDijk2014
ER  -

download .riscopy to clipboard