Aortic calcification, arterial stiffness and bone mineral density in patients with COPD☆

Charlotte E. Bolton; Carmel M. McEniery; Vimal Raj; Barry J. McDonnell; Adrian K. Dixon; Margaret Munnery; Ramsey Sabit; Nicholas Screaton; Michael Stone; Ian B. Wilkinson; Dennis J. Shale; John R. Cockcroft

doi:10.1016/j.artres.2011.01.001

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Volume 5, Issue 1, March 2011, Pages 30 - 36

Aortic calcification, arterial stiffness and bone mineral density in patients with COPD☆

Authors

Charlotte E. Bolton^a^{, b}^{, *}, Carmel M. McEniery^c, Vimal Raj^d, Barry J. McDonnell^b^{, e}, Adrian K. Dixon^f, Margaret Munnery^b, Ramsey Sabit^g, Nicholas Screaton^d, Michael Stone^h, Ian B. Wilkinson^c, Dennis J. Shale^b, John R. Cockcroft^b

^aNIHR Nottingham Respiratory Biomedical Research Unit, Clinical Sciences Building, University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK

^bWales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UK

^cDepartment of Clinical Pharmacology, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK

^dPapworth Hospital NHS Trust, Papworth Everard, Cambridge CB23 3RE, UK

^eCardiff School of Health Sciences, University of Wales Institute, Cardiff, UK

^fDepartment of Radiology, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK

^gRespiratory Medicine, Cardiff and Vale University NHS Trust, Cardiff, UK

^hBone Research Unit, Cardiff University, Cardiff, UK

^☆

The work was carried out at Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UK.

^*Corresponding author. NIHR Nottingham Respiratory Biomedical Research Unit, Clinical Sciences Building, University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK. Tel.: +44 (0) 115 8231317; fax: +44 (0) 115 8231946. E-mail address: charlotte.bolton@nottingham.ac.uk (C.E. Bolton).

Corresponding Author

Charlotte E. Bolton

Received 5 November 2010, Revised 5 January 2011, Accepted 7 January 2011, Available Online 4 February 2011.

DOI: 10.1016/j.artres.2011.01.001 How to use a DOI?
Keywords: Aortic stiffness; Pulse wave velocity; Osteoporosis; Lung function
Abstract: Background: Increased arterial stiffness, using aortic pulse wave velocity (PWV) has been demonstrated in patients with COPD. However, mechanisms underlying this remain unclear. We explored the contribution of aortic calcification to large artery haemodynamics and its association to bone mineral density (BMD) in patients with confirmed COPD.

Methods: Patients with COPD, free of maintenance oral corticosteroids, renal disease, diabetes or known cardiovascular disease (n = 45), 27 male, mean (SD) age 66(7) years underwent unenhanced thoraco-abdominal computed tomography to determine quantitative aortic calcium content using a volume scoring method. Aortic PWV was measured. A subgroup (n = 29) had BMD determined.

Results: All patients had some evidence of aortic calcification. Aortic PWV was related to log₁₀ calcification in abdominal aorta (r = 0.34, p = 0.025) and to semi-quantitative assessment in the ascending and descending thoracic aorta (r = 0.47 and r = 0.39, both p < 0.01). Log₁₀ calcium was inversely related to BMD hip (r = −0.43), p = 0.02. Both aortic PWV and log₁₀ calcium were related to age, which on multiple regression was the independent variable.

Conclusions: Aortic calcification is related to aortic stiffness, an independent predictor of cardiovascular mortality and morbidity, and inversely to BMD in patients with COPD. Given, both cardiovascular disease and osteoporosis are common in patients with COPD, determining underlying mechanisms are essential as potential therapeutic targets.
Open Access: This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue

Journal: Artery Research
Volume-Issue: 5 - 1
Pages: 30 - 36
Publication Date: 2011/02/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.01.001 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Charlotte E. Bolton
AU  - Carmel M. McEniery
AU  - Vimal Raj
AU  - Barry J. McDonnell
AU  - Adrian K. Dixon
AU  - Margaret Munnery
AU  - Ramsey Sabit
AU  - Nicholas Screaton
AU  - Michael Stone
AU  - Ian B. Wilkinson
AU  - Dennis J. Shale
AU  - John R. Cockcroft
PY  - 2011
DA  - 2011/02/04
TI  - Aortic calcification, arterial stiffness and bone mineral density in patients with COPD☆
JO  - Artery Research
SP  - 30
EP  - 36
VL  - 5
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.01.001
DO  - 10.1016/j.artres.2011.01.001
ID  - Bolton2011
ER  -

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