Correlation between fetuin-A and matrix Gla protein levels in human serum

Katsuhito Mori; Yuji Ikari; Shuichi Jono; Masanori Emoto; Atsushi Shioi; Hidenori Koyama; Tetsuo Shoji; Eiji Ishimura; Masaaki Inaba; Kazuhiro Hara; Yoshiki Nishizawa

doi:10.1016/j.artres.2010.06.002

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Volume 4, Issue 3, September 2010, Pages 91 - 93

Correlation between fetuin-A and matrix Gla protein levels in human serum

Authors

Katsuhito Mori^a^{, *}, Yuji Ikari^c, Shuichi Jono^a, Masanori Emoto^a, Atsushi Shioi^b, Hidenori Koyama^a, Tetsuo Shoji^a, Eiji Ishimura^a, Masaaki Inaba^a, Kazuhiro Hara^c, Yoshiki Nishizawa^a

^aThe Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan

^bThe Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan

^cThe Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan

^*Corresponding author. Tel.: +81 6 6645 3806; fax: +81 6 6645 3808. E-mail address: ktmori@med.osaka-cu.ac.jp (K. Mori).

Corresponding Author

Katsuhito Mori

Received 16 March 2010, Revised 27 May 2010, Accepted 7 June 2010, Available Online 24 July 2010.

DOI: 10.1016/j.artres.2010.06.002 How to use a DOI?
Keywords: Fetuin-A; Matrix Gla protein; Osteoprotegerin; Osteopontin; Vascular calcification
Abstract: Background: Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN.

Methods: We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA.

Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels.

Conclusions: We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 4 - 3
Pages: 91 - 93
Publication Date: 2010/07/24
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2010.06.002 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Katsuhito Mori
AU  - Yuji Ikari
AU  - Shuichi Jono
AU  - Masanori Emoto
AU  - Atsushi Shioi
AU  - Hidenori Koyama
AU  - Tetsuo Shoji
AU  - Eiji Ishimura
AU  - Masaaki Inaba
AU  - Kazuhiro Hara
AU  - Yoshiki Nishizawa
PY  - 2010
DA  - 2010/07/24
TI  - Correlation between fetuin-A and matrix Gla protein levels in human serum
JO  - Artery Research
SP  - 91
EP  - 93
VL  - 4
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.06.002
DO  - 10.1016/j.artres.2010.06.002
ID  - Mori2010
ER  -

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