A systematic appraisal of ventricular–aortic load in African American men

Kevin S. Heffernan; Bo Fernhall

doi:10.1016/j.artres.2009.02.003

<Previous Article In Issue

Next Article In Issue>

Volume 3, Issue 2, June 2009, Pages 65 - 72

A systematic appraisal of ventricular–aortic load in African American men

Authors

Kevin S. Heffernan^a^{, b}^{, *}, Bo Fernhall^a

^aDepartment of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL, USA

^bDepartment of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA, USA

^*Corresponding author. Molecular Cardiology Research Institute and the Department of Medicine, Division of Cardiology, Tufts Medical Center, Boston, MA, USA. E-mail address: kheffernan@tuftsmedicalcenter.org (K.S. Heffernan).

Corresponding Author

Kevin S. Heffernan

Received 10 December 2008, Revised 29 January 2009, Accepted 16 February 2009, Available Online 14 March 2009.

DOI: 10.1016/j.artres.2009.02.003 How to use a DOI?
Keywords: Arterial stiffness; Wave reflection; Left ventricle; Hemodynamic
Abstract: Background: We examined several measures of ventricular–vascular load as they relate to ECG-derived measures of left ventricular (LV) morphology in a cross-section of 19 young African American and 19 white men.

Methods: Measures of steady and pulsatile LV load derived from aortic blood pressure waveforms included: aortic characteristic impedance (Z_c), effective arterial elastance (E_a), arterial compliance, aortic reservoir function, aortic wave reflection (AIx), and total peripheral resistance (TPR). Also derived from the pressure waveform were the rate pressure product (RPP), tension–time index (TTI), diastolic pressure–time index (DPTI), and the subendocardial viability ratio (SEVR). ECG was used to measure R-wave area, R-wave amplitude, and QRS duration as crude proxies of LV morphology.

Results: African American men had greater E_a, AIx, TPR and reduced aortic compliance compared with white men (all p < 0.05). There was a positive association between E_a, Z_c, TPR and LV morphology (p < 0.05). There was an inverse association between arterial compliance and LV morphology (p < 0.05). AIx was not associated with LV morphology. There were no racial differences in aortic reservoir function, RPP, TTI, DPTI, or SEVR. Aortic reservoir function was positively associated with DPTI and SEVR (p < 0.05) and inversely associated with RPP (p < 0.05).

Conclusions: In young African American men, LV morphology is influenced by LV load stemming from aortic stiffness and vascular resistance more-so than augmented pressure from wave reflections. Aortic reservoir function is preserved in young African American men, balancing myocardial oxygen supply and demand in the presence of altered vascular–ventricular coupling and LV remodeling.
Copyright: © 2009 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access: This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 3 - 2
Pages: 65 - 72
Publication Date: 2009/03/14
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.02.003 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Kevin S. Heffernan
AU  - Bo Fernhall
PY  - 2009
DA  - 2009/03/14
TI  - A systematic appraisal of ventricular–aortic load in African American men
JO  - Artery Research
SP  - 65
EP  - 72
VL  - 3
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.02.003
DO  - 10.1016/j.artres.2009.02.003
ID  - Heffernan2009
ER  -

download .riscopy to clipboard