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Volume 1, Issue 1, June 2007, Pages 20 - 25

Sodium excretion as a modulator of genetic influence on arterial stiffness and other cardiovascular phenotypes

Authors
Katarzyna Stolarza, *, Tatiana Kuznetsovab, f, Wiktoria Wojciechowskaa, Jitka Seidlerovad, Edoardo Casigliac, Jan Filipovskýd, Jan Peleškae, Yuri Nikitinf, Jan A. Staessenb, Kalina Kawecka-Jaszcza, on behalf of the European Project On Genes in Hypertension (EPOGH) Investigators
aFirst Department of Cardiology and Hypertension, Medical College, Jagiellonian University, Kopernika 17, 31-501, Cracow, Poland
bStudy Coordinating Centre, Hypertension and Cardiovascular Rehabilitation Unit, Department of Molecular and Cardiovascular Research, University of Leuven, Leuven, Belgium
cDepartment of Clinical and Experimental Medicine, University of Padova, Italy
dCharles University, Pilsen, Czech Republic
eGeneral Faculty Hospital, Prague, Czech Republic
fInstitute of Internal Medicine, Novosibirsk, Russian Federation

First presented at Artery 6, Athens, Greece, 2223 September 2006

*Corresponding author. Tel.: +48 12 424 73 00; fax: +48 12 424 73 20. E-mail address: katarzyna_stolarz@poczta.onet.pl (K. Stolarz).
Corresponding Author
Katarzyna Stolarz
Available Online 6 June 2007.
DOI
10.1016/j.artres.2007.03.002How to use a DOI?
Keywords
Genetics; Arterial stiffness; Left ventricular mass; Heart rate variability; Sodium
Abstract

Hypertension is a chronic age-related disorder, affecting nearly 20% of all adult Europeans. This disease entails debilitating cardiovascular complications and is the leading cause for drug prescriptions in Europeans older than 50 years. Intensive research over the past two decades has so far failed to identify common genetic polymorphisms with a major impact on blood pressure or associated cardiovascular phenotypes, suggesting that multiple genes each with a minor impact, along with gene–gene and gene–environment interactions, play a role. The European Project on Genes in Hypertension (EPOGH) is a large-scale, family-based study in which participants from seven different populations were phenotyped and genotyped according to standardized procedures. The EPOGH demonstrated that phenotype–genotype relations strongly depend on host factors such as gender and lifestyle, in particular salt intake as reflected by the 24-h urinary excretion of sodium. Individuals with the same genetic predisposition had different vascular stiffness, left ventricular mass or heart rate variability, depending on whether they ate a high-sodium or a low-sodium diet. The EPOGH therefore highlights the concept that phenotype–genotype relations can only be studied within a defined ecogenetic context.

Copyright
© 2007 Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
1 - 1
Pages
20 - 25
Publication Date
2007/06/06
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2007.03.002How to use a DOI?
Copyright
© 2007 Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Katarzyna Stolarz
AU  - Tatiana Kuznetsova
AU  - Wiktoria Wojciechowska
AU  - Jitka Seidlerova
AU  - Edoardo Casiglia
AU  - Jan Filipovský
AU  - Jan Peleška
AU  - Yuri Nikitin
AU  - Jan A. Staessen
AU  - Kalina Kawecka-Jaszcz
AU  - on behalf of the European Project On Genes in Hypertension (EPOGH) Investigators
PY  - 2007
DA  - 2007/06/06
TI  - Sodium excretion as a modulator of genetic influence on arterial stiffness and other cardiovascular phenotypes
JO  - Artery Research
SP  - 20
EP  - 25
VL  - 1
IS  - 1
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2007.03.002
DO  - 10.1016/j.artres.2007.03.002
ID  - Stolarz2007
ER  -