Aortic stiffness in obese children and adolescents: Comparison of two distance measures of carotid–femoral pulse wave velocity

Kristian Nebelin Hvidt; Michael Hecht Olsen; Jens-Christian Holm; Hans Ibsen

doi:10.1016/j.artres.2013.09.004

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Volume 7, Issue 3-4, September 2013, Pages 186 - 193

Aortic stiffness in obese children and adolescents: Comparison of two distance measures of carotid–femoral pulse wave velocity

Authors

Kristian Nebelin Hvidt^a^{, b}^{, *}, Michael Hecht Olsen^c^{, d}, Jens-Christian Holm^b, Hans Ibsen^a

^aDivision of Cardiology, Department of Medicine, Copenhagen University Hospital Holbæk, Smedelundsgade 60, 4300 Holbæk, Denmark

^bThe Children’s Obesity Clinic, Department of Paediatrics, Copenhagen University Hospital Holbæk, Smedelundsgade 60, 4300 Holbæk, Denmark

^cCardiovascular and Metabolic Preventive Clinic, Department of Endocrinology, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark

^dHypertension in Africa Research Team (HART), School for Physiology, Nutrition and Consumer Sciences, North-West University, Potchefstroom, South Africa

^*Corresponding author. Division of Cardiology, Department of Medicine, Copenhagen University Hospital Holbæk, Smedelundsgade 60, 4300 Holbæk, Denmark. Tel.: +45 59 48 40 73. E-mail addresses: krhv@regionsjaelland.dk (K. Nebelin Hvidt), mho@dadlnet.dk (M.H. Olsen), jhom@regionsjaelland.dk (J.-C. Holm), hib@regionsjaelland.dk (H. Ibsen).

Corresponding Author

Kristian Nebelin Hvidt

Received 11 July 2013, Revised 19 August 2013, Accepted 6 September 2013, Available Online 27 September 2013.

DOI: 10.1016/j.artres.2013.09.004 How to use a DOI?
Keywords: Adolescence; Aortic stiffness; Augmentation index; Blood pressure; Children; Obesity; Pulse wave velocity
Abstract: Background: The methodology of the gold standard for measuring aortic stiffness, carotid–femoral pulse wave velocity (cfPWV), has been revised in respect to the choice of distance measure. In order to clarify whether increased aortic stiffness is present in obese children and adolescents we investigated cfPWV with the previous (cfPWV-subtracted) and a newly revised methodology (cfPWV-direct).

Methods: In a cross-sectional design, 104 obese patients with age 10–18 years newly referred to the Children’s Obesity Clinic were compared to 50 healthy control individuals. CfPWV was measured non-invasively using the SphygmoCor device, while all distance measures were made with a calliper.

Results: Opposite to the direct distance, the subtracted distance differed across study groups in relation to height (P < 0.006). CfPWV-subtracted was significantly higher for the obese (4.5 m/s CI: 4.4–4.6 vs. 4.3 m/s CI: 4.2–4.5, P = 0.03), whereas cfPWV-direct was significantly lower (4.8 m/s CI: 4.7–4.9 vs. 5.1 m/s CI: 4.9–5.3, P = 0.008). In multiple regression, being obese did not significantly influence cfPWV-subtracted (β = 0.126, CI: −0.04–0.29, NS) whereas it significantly reduced cfPWV-direct (β = −0.34, CI: −0.53–0.15, P < 0.001), when adjusting for age, gender, mean arterial blood pressure and heart rate. Both groups had normal values of cfPWV-subtracted in respect to a European reference material.

Conclusion: The distance measure of cfPWV-direct was associated similarly to height across study groups. Adjusted for main confounders, cfPWV-subtracted was equal whereas cfPWV-direct was reduced in obese compared to normal weighted children and adolescents.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 7 - 3-4
Pages: 186 - 193
Publication Date: 2013/09/27
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2013.09.004 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Kristian Nebelin Hvidt
AU  - Michael Hecht Olsen
AU  - Jens-Christian Holm
AU  - Hans Ibsen
PY  - 2013
DA  - 2013/09/27
TI  - Aortic stiffness in obese children and adolescents: Comparison of two distance measures of carotid–femoral pulse wave velocity
JO  - Artery Research
SP  - 186
EP  - 193
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.09.004
DO  - 10.1016/j.artres.2013.09.004
ID  - NebelinHvidt2013
ER  -

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