Vascular adaptation to extreme conditions: The role of hypoxia

Rosa Maria Bruno; Lorenzo Ghiadoni; Lorenza Pratali

doi:10.1016/j.artres.2016.02.003

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Volume 14, Issue C, June 2016, Pages 15 - 21

Vascular adaptation to extreme conditions: The role of hypoxia

Authors

Rosa Maria Bruno^a^{, b}^{, *}, Lorenzo Ghiadoni^a, Lorenza Pratali^b

^aDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

^bInstitute of Clinical Physiology – CNR, Pisa, Italy

^*Corresponding author. Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56124 Pisa, Italy. Tel.: +39 050 992914; fax: +39 050 992409. E-mail address: rosam.bruno@gmail.com (R.M. Bruno).

Corresponding Author

Rosa Maria Bruno

Received 9 October 2015, Revised 3 February 2016, Accepted 4 February 2016, Available Online 22 February 2016.

DOI: 10.1016/j.artres.2016.02.003 How to use a DOI?
Keywords: Hypoxia; High altitude; Endothelial function; Arterial stiffness; Carotid remodeling
Abstract: The study of vascular adaptation to extreme conditions, and in particular to hypoxia, represents a unique opportunity in cardiovascular physiology, with relevant translational implications. First, it has crucial clinical consequences for about 140 million people worldwide living at high altitude and chronically exposed to hypobaric hypoxia. Second, an increasing number of lowlanders are exposed to high altitude for recreational or working purposes, including aged, diseased individuals: in these cases, hypoxia could be a trigger for acute cardiovascular events. Finally, hypoxia plays a major role in the pathogenesis of many diseases and chronic conditions, as respiratory (i.e. chronic obstructive pulmonary disease and obstructive sleep apnea syndrome) and cardiovascular disorders (i.e. heart failure, ischemic heart disease and cerebrovascular disease). Thus, results from field studies at high altitude might be important for a deeper understanding of their pathophysiology. This review is aimed at summarizing the main findings in the field of chronic and acute vascular adaptation to hypoxia, focusing on the role of nitric oxide (NO) and endothelial function, as well as large artery behavior.
Copyright: © 2016 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 14 - C
Pages: 15 - 21
Publication Date: 2016/02/22
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2016.02.003 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Rosa Maria Bruno
AU  - Lorenzo Ghiadoni
AU  - Lorenza Pratali
PY  - 2016
DA  - 2016/02/22
TI  - Vascular adaptation to extreme conditions: The role of hypoxia
JO  - Artery Research
SP  - 15
EP  - 21
VL  - 14
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.02.003
DO  - 10.1016/j.artres.2016.02.003
ID  - Bruno2016
ER  -

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