Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value
- https://doi.org/10.1016/j.artres.2016.10.154How to use a DOI?
- Arterial stiffness, Applanation tonometry, Central aortic pressure, Clinical outcomes, Hemodynamics, Pulse waveform analysis, Wave reflection
Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular (CV) events. However, recent clinical evidence suggests that central aortic pressure (CAP) provides additional information for assessing CV risk than brachial blood pressure (BrBP). Central hemodynamics can now be non-invasively assessed with a number of devices, however, the methodology employed to measure CAP, in order to better identify the patients at higher CV risk in clinical practice, is still controversial. The purpose of this article is to review the technology behind the non-invasive measurement of CAP via the effects of different classes of antihypertensive drugs on CAP and the data supporting the predictive value of assessing CAP on clinical outcomes, and to foster the transfer of methodological knowledge from clinical trials into routine clinical practice.
- © 2016 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - JOUR AU - Bryan Williams AU - Patrick Brunel AU - Peter S. Lacy AU - Fabio Baschiera AU - Dion H. Zappe AU - Kazuomi Kario AU - John Cockcroft PY - 2016 DA - 2016/12 TI - Application of non-invasive central aortic pressure assessment in clinical trials: Clinical experience and value JO - Artery Research SP - 1 EP - 15 VL - 17 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2016.10.154 DO - https://doi.org/10.1016/j.artres.2016.10.154 ID - Williams2016 ER -