Arterial baroreflex sensitivity: Relationship with peripheral chemoreflex in patients with chronic heart failure
- https://doi.org/10.1016/j.artres.2018.10.002How to use a DOI?
- Arterial baroreflex, Peripheral chemoreflex, Heart failure
Background: The purpose of this study was to evaluate the relationship between the breath-holding duration and the sensitivity of the arterial baroreflex, as well as the prognostic value of the breath-holding test in the assessment of decreased baroreflex sensitivity (BRS) in patients with chronic heart failure (CHF).
Methods: The study was conducted on 87 patients with CHF. In all participants, the breath-holding test was performed in the morning, while the single-breath carbon dioxide test was performed on the next day; the injection method was used to evaluate BRS. Other parameters, including pulse wave velocity (PWV), N-terminal pro-brain natriuretic peptide (NT-proBNP) level, and spirometry and echocardiography findings, were also evaluated.
Results: A significant correlation was found between BRS and the following two parameters: breath-holding duration and left ventricular ejection fraction (all p < 0.05) and a significant negative correlation between BRS and the following three parameters: age, NT-proBNP level, and PWV (all p < 0.05). After analysis, only the breath-holding duration remained significant in our model (R2 adjusted for the model, 0.55). The breath-holding duration was a good predictor of decreased BRS (<3 ms/mmHg), with a cut-off point of <34 s [area under curve, 0.876 (0.778–0.937, p < 0.0001)].
Conclusion: A reduced breath-holding duration is associated with decreased sensitivity of the arterial baroreflex. If the duration of the breath-holding test is <34 s, decreased BRS is predicted. This test can be effectively used for the initial assessment of the level of the reflex regulation of the cardiorespiratory system in patients with CHF.
- © 2018 The Authors. Published by Elsevier B.V. on behalf of Association for Research into Arterial Structure and Physiology.
- Open Access
- This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - JOUR AU - Nikita Trembach AU - Igor Zabolotskikh PY - 2018 DA - 2018/10 TI - Arterial baroreflex sensitivity: Relationship with peripheral chemoreflex in patients with chronic heart failure JO - Artery Research SP - 9 EP - 15 VL - 24 IS - C SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2018.10.002 DO - https://doi.org/10.1016/j.artres.2018.10.002 ID - Trembach2018 ER -