Therapeutic Effect of a Novel Human Parathyroid Hormone Analog Nasal Drops on Osteoporosis Rats
- DOI
- 10.2991/ssphe-17.2017.1How to use a DOI?
- Keywords
- human parathyroid hormone; nasal drops; osteoporosis; trabecula of bone
- Abstract
In this study, the therapeutic effect of a novel human parathyroid hormone analogs nasal drops on ovariectomized rats was evaluated. Thirty-two of 40 3-month-old female Sprague-Dawley rats were ovariectomized and 8 received sham operation. Thirteen weeks later, ovariectomized rats were randomly and averagely divided into 4 groups: low dose, middle dose and high dose group (31.25, 125, 500 g/rat respectively) and vehiculum group (0.5 mL/rat). Each group was administered to the nasal drops. Another 8 sham-operated rats were treated in the same way as those of vehiculum group. All rats were administered daily. After 16 weeks of continuous administration, the osteogenic ability was compared between rats in each group. The results indicated that compared with vehiculum group, significant increments in the dry weights of femur, trabecular area and trabecular width were shown in the groups treated with middle dose and high dose hPTH'. The results showed dose dependence. It is concluded that hPTH' nasal drop is effective in stimulating bone formation and improving skeletal microarchitecture and potentially an effective therapeutical agent on osteoporosis.
- Copyright
- © 2017, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Jiao Feng AU - Yan Zhu AU - Shuang Gao AU - Shuyan Ren AU - Rongyue Cao PY - 2017/05 DA - 2017/05 TI - Therapeutic Effect of a Novel Human Parathyroid Hormone Analog Nasal Drops on Osteoporosis Rats BT - Proceedings of the International Conference on Social Science, Public Health and Education (SSPHE 2017) PB - Atlantis Press SP - 1 EP - 5 SN - 2352-5398 UR - https://doi.org/10.2991/ssphe-17.2017.1 DO - 10.2991/ssphe-17.2017.1 ID - Feng2017/05 ER -