Management of Recurrent Regional Nasopharyngeal Carcinoma

DOI

10.2991/ahsr.k.220206.034How to use a DOI?

Keywords

recurrent nasopharyngeal carcinoma; neck dissection; adjuvant chemotherapy

Abstract

Treatment result for nasopharyngeal carcinoma has improved drastically due to introduction of chemotherapy and radiotherapy combination. However, regional failure is still a common finding which occurs to 3-10% patients. Local failure can be divided into 2, residual and recurrent disease. Residual or recurrent disease is defined as confirmations of disease occurring within 6 months following treatment. A 45-year-old male presenting with a neck mass, nosebleed, and obstructed nose. From physical examination there were multiple cervical lymph nodes enlargement in level 3 and 4 and an exophytic mass on the the roof of nasopharyng. We evaluated the patient using CT scan and biopsy. The patient was diagnosed with WHO III T2N2M0 nasopharyngeal carcinoma. Following chemoradioation, patient still complained of neck mass. PET scan showed sign of malignancy and metastasis. Patient underwent neck dissection. Histology examination showed no viable tumor cell therefore patient was diagnosed with nonspecific chronic lymphadenopathy. Following treatment for nasopharyngeal carcinoma, clinician must assess extent of disease or distant metastasis by CT scan, MRI, or PET scan. In case of which residual, recurrent, persistent, or progressive disease is confirmed, then patient had to undergone neck dissection or systemic therapy (radiation or chemotherapy). Study by Chen et al showed that selective neck dissection (SND) procedure had a favorable overall survival, disease-free survival, and regional-free survival compared to radical neck dissection (RND). Other study by Yang et al showed that adjuvant chemotherapy did not have significant correlation with overall survival, failure-free survival, local relapse-free survival, and distant metastasis-free survival. For treatment of recurrent nasopharyngeal carcinoma, clinician must consider the need for adjuvant chemotherapy or neck dissection procedure. Study showed that SND had a better effectivity compared to RND. However, it still can’t be concluded whether SND procedure is better than adjuvant chemotherapy.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Marlinda Adham
AU  - Gita Aryanti
PY  - 2022
DA  - 2022/02/21
TI  - Management of Recurrent Regional Nasopharyngeal Carcinoma
BT  - Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)
PB  - Atlantis Press
SP  - 176
EP  - 183
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220206.034
DO  - 10.2991/ahsr.k.220206.034
ID  - Adham2022
ER  -