The Differences of Programmed Death Ligand 1 Expression Between the Early Stages and Advanced Stages of Nasopharyngeal Carcinoma in DR. M Djamil Padang Hospital

DOI

10.2991/ahsr.k.220206.010How to use a DOI?

Keywords

Nasopharyngeal carcinoma; PD-L1; PD-1; Immune checkpoint; immunotherapy

Abstract

Nasopharyngeal carcinoma (NPC) is a malignant tumor originating from the nasopharyngeal epithelial cells. Cell-mediated immunity has an important role in growth and development of cancer. Many studies have been conducted to predict the existence of an important relationship between immune checkpoints Programmed Death-1 (PD-1) and Programmed Death Ligand-1(PD-L1) with NPC. The research of checkpoint blocking antibodies against PD-1 and PD-L1 shows promising results for cancer immunotherapy. An analytical cross sectional study was conducted on 30 biological preparations for NPC patients consisting of 15 biological preparations for NPC patients with early stage and 15 biological preparations for NPC patients with advanced stages. Molecular examinations are carried out to see the expression of PD-L1 by the immunohistochemical (IHC) method on each of biological preparations,. Data were statistically analyzed with computer programs and were stated to be significant if p<0.05. In this study, a high PD-L1 expression was obtained in 3 of early stage NPC patients and 4 of advanced stage NPC patients using the Tumor Proportion Score assessment. Meanwhile, using the Immunoreactive Score assessment, a high PD-L1 expression was obtained in 1of early stage NPC patient and 4 of advanced stage NPC patients. Statistically, there was no significant difference in PD-L1 expression between early stage and advanced stage at NPC at Dr. M Djamil Padang Hospital with p> 0.05 A High PD-L1 expression was found to be more prevalent in the advanced stage of NPC patient but there was no significant difference in PD-L1 expression between early stage and advanced stage at NPC at Dr. M Djamil Padang Hospital

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

Download article (PDF)

TY  - CONF
AU  - Nadya Dwi Karsa
AU  - Sukri Rahman
AU  - Al Hafiz
AU  - Hirowati Ali
AU  - Hafni Bachtiar
PY  - 2022
DA  - 2022/02/21
TI  - The Differences of Programmed Death Ligand 1 Expression Between the Early Stages and Advanced Stages of Nasopharyngeal Carcinoma in DR. M Djamil Padang Hospital
BT  - Proceedings of the 2nd Global Health and Innovation in conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021)
PB  - Atlantis Press
SP  - 44
EP  - 50
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220206.010
DO  - 10.2991/ahsr.k.220206.010
ID  - Karsa2022
ER  -