Meta-Analysis on the effectiveness of the Use of Prophylactic Antibiotics in Preventing Surgical Site Infection in Patients with Hernia Surgery

Heru Wijono; Febryza Kristin; Beryl Bayanaka Agustha Peerera; Fauna Herawati; Rika Yulia

doi:10.2991/978-94-6463-322-1_3

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Meta-Analysis on the effectiveness of the Use of Prophylactic Antibiotics in Preventing Surgical Site Infection in Patients with Hernia Surgery

Authors

Heru Wijono¹, Febryza Kristin², Beryl Bayanaka Agustha Peerera³, Fauna Herawati², Rika Yulia²^{, *}

¹Doctoral Program, Faculty of Public Health, University of Airlangga, Jalan Dr. Ir. H. Soekarno, Mulyorejo, Kec. Mulyorejo, Surabaya, 60115, Indonesia

²Faculty of Pharmacy, University of Surabaya, Jalan Raya Kalirungkut, Surabaya, 60293, Indonesia

³National Hospital, Jl. Lontar Indah VII Blok PA 11 No. 58, Lontar, Kec. Sambikerep, Surabaya, 60216, Indonesia

^*Corresponding author. Email: rika_y@staff.ubaya.ac.id

Corresponding Author

Rika Yulia

Available Online 30 December 2023.

DOI: 10.2991/978-94-6463-322-1_3 How to use a DOI?
Keywords: prophylactic antibiotics; surgical site infection; hernia surgery
Abstract: The administration of prophylactic antibiotics in hernia surgery patients is currently controversial, with varying opinions regarding their necessity. The European Hernia Society guideline does not recommend prophylactic antibiotics in patients with hernia surgery, while recent studies found that prophylactic antibiotics in hernia surgery patients can be given routinely and are effective in reducing surgical site infections. This study aims to determine the effectiveness of prophylactic antibiotics for preventing surgical site infection in patients with hernia surgery. This research is a systematic review using articles with a randomized controlled trial (RCT) research design using Indonesia and English language within the last 10-year of publication year. Twenty-four RCTs that met the inclusion and exclusion criteria were used to address the research problem. The results showed that a total of 207 patients experienced the incidence of surgical site infection in patients with hernia surgery, including 78 patients (4.5%) in the antibiotic group and 129 patients (7.88%) in the control. A significant difference was found between the antibiotic and the control groups in preventing surgical site infections, with a P-value < 0.0001 (OR = 0.56; 95% CI = 0.42–0.75). Conclusion: Surgical site infections are less likely to develop when a prophylactic antibiotic is administered to patients with hernia surgery.
Copyright: © 2023 The Author(s)
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title: Proceedings of the Conference on Natural Resources And Life Sciences 2022 (NRLS-BIO 2022)
Series: Advances in Biological Sciences Research
Publication Date: 30 December 2023
ISBN: 978-94-6463-322-1
ISSN: 2468-5747
DOI: 10.2991/978-94-6463-322-1_3 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

ris enw bib

TY  - CONF
AU  - Heru Wijono
AU  - Febryza Kristin
AU  - Beryl Bayanaka Agustha Peerera
AU  - Fauna Herawati
AU  - Rika Yulia
PY  - 2023
DA  - 2023/12/30
TI  - Meta-Analysis on the effectiveness of the Use of Prophylactic Antibiotics in Preventing Surgical Site Infection in Patients with Hernia Surgery
BT  - Proceedings of the Conference on Natural Resources And Life Sciences 2022 (NRLS-BIO 2022)
PB  - Atlantis Press
SP  - 18
EP  - 26
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-322-1_3
DO  - 10.2991/978-94-6463-322-1_3
ID  - Wijono2023
ER  -

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