Proceedings of the 9th International Seminar on Tropical Animal Production (ISTAP 2021)

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Anticancer Potential of Lactobacillus acidophilus IIA-2B4 Extracts Against MCF-7 Breast Cancer Cell Line

Authors
Reza Adiyoga*, Irma Isnafia Arief1, Cahyo Budiman1
1Faculty of Animal Science, IPB University
*Corresponding author. Email: rezadiyoga@gmail.com
Corresponding Author
Reza Adiyoga
Available Online 24 February 2022.
DOI
10.2991/absr.k.220207.041How to use a DOI?
Keywords
Anticancer; MCF-7; breast cancer; Lactobacillus acidophilus IIA-2B4
Abstract

Lactobacillus acidophilus IIA-2B4 is an indigenous lactic acid bacteria (LAB) extracted from Ongole Cross beef. Previous studies shown that this bacteria has probiotic properties such as antibacterial activity and antiproliferative effect on HeLa cervix cancer cell line. This study aimed to investigate the anticancer properties of Lactobacillus acidophilus IIA-2B4 against MCF-7 breast cancer cell line. Intracellular and extracellular extracts were obtained and MTT assay was used to determine the antiproliferative activity, along with doxorubicin as control. The concentration of extract used in MTT assay were 0, 15, 50, 100, and 200 ppm. The result shown that intracellular extracts have a better overall antiproliferative activity compared to extracellular extracts. Percentage of inhibition also increase along with higher level of concentration. Highest percentage of inhibtion by intracellular extract was 97.49% ± 1.197, meanwhile the highest percentage of inhibtion by extracellular extract was 97.03% ± 0.434. The lowest concentration of intracellular extract with antiproliferative activity similiar to that of doxorubicin was found in 50 ppm with 93.84% ± 2.220. The results indicate that both extracts have anticancer potential against MCF-7 breast cancer cell line and may provide as a natural alternative to treat and prevent cancer.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

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Volume Title
Proceedings of the 9th International Seminar on Tropical Animal Production (ISTAP 2021)
Series
Advances in Biological Sciences Research
Publication Date
24 February 2022
ISBN
978-94-6239-542-8
ISSN
2468-5747
DOI
10.2991/absr.k.220207.041How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article under the CC BY-NC license.

Cite this article

risenwbib
TY  - CONF
AU  - Reza Adiyoga
AU  - Irma Isnafia Arief
AU  - Cahyo Budiman
PY  - 2022
DA  - 2022/02/24
TI  - Anticancer Potential of Lactobacillus acidophilus IIA-2B4 Extracts Against MCF-7 Breast Cancer Cell Line
BT  - Proceedings of the 9th International Seminar on Tropical Animal Production (ISTAP 2021)
PB  - Atlantis Press
SP  - 194
EP  - 197
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.220207.041
DO  - 10.2991/absr.k.220207.041
ID  - Adiyoga2022
ER  -