Proceedings of the 4th International Symposium on Health Research (ISHR 2019)

The Effect of Anastatica hierochuntica L. Extract on the Histology of Myometrial Cells and Prostaglandin levels (PGE2, PGF2α) in Pregnant Mice

Authors
Heny Astutik, Budi Santoso, Mangestuti Agil
Corresponding Author
Heny Astutik
Available Online 22 February 2020.
DOI
10.2991/ahsr.k.200215.016How to use a DOI?
Keywords
Anastatica hierochuntica L., myometrial cells, prostaglandins, pregnant mice
Abstract

Anastatica hierochuntica L. is well known as a traditional medicine which brings benefit to the final trimester of pregnancy by increase uterine contractions. This study aimed to analyze the effect of A. hierochuntica L. extract on the histology of myometrial cells and prostaglandin levels (PGE2 and PGF2α) of pregnant mice. The mice were divided into three groups: (1) control group, treated by 0.5% CMC solution 10 ml/kgbw/day; (2) two treatment groups that treated by A. hierochuntica L. extract with 100 and 150 mg/kgbw/day doses, respectively. Uterine tissue was collected for histological analysis and blood serum was collected to examine the PGE2 and PGF2α levels. It obtained that myometrial hypertrophy increased significantly in the treatment groups (p = 0.001) than in the control group. Moreover, there were significant differences in the PGE2 levels (p = 0.001) and PGF2α levels (p = 0.000) between the control group and the treatment groups. The 100 mg/kgbw/day dose had a greater effect on myometrial hypertrophy than 150 mg/kgbw/day, which resulted in a higher increase of PGE2 and PGF2α levels. Hence, it was concluded that the 100 mg/kgbw/day dose of A. hierochuntica L. extract was the appropriate dose for increasing prostaglandin levels.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 4th International Symposium on Health Research (ISHR 2019)
Series
Advances in Health Sciences Research
Publication Date
22 February 2020
ISBN
978-94-6252-911-3
ISSN
2468-5739
DOI
10.2991/ahsr.k.200215.016How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Heny Astutik
AU  - Budi Santoso
AU  - Mangestuti Agil
PY  - 2020
DA  - 2020/02/22
TI  - The Effect of Anastatica hierochuntica L. Extract on the Histology of Myometrial Cells and Prostaglandin levels (PGE2, PGF2α) in Pregnant Mice
BT  - Proceedings of the 4th International Symposium on Health Research (ISHR 2019)
PB  - Atlantis Press
SP  - 81
EP  - 86
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200215.016
DO  - 10.2991/ahsr.k.200215.016
ID  - Astutik2020
ER  -