Molecular Genetics and Epigenetics of Ankyloglossia

DOI

10.2991/idsm-17.2018.14How to use a DOI?

Keywords

Ankyloglossia, Tongue tie, Genetics, Epigenetics, Lingual frenulum

Abstract

Ankyloglossia is an autosomal dominant condition with in complete penetrence, haracterized by frenulum lingual hypertrophy that produces a thicker and shorter tongue, which may cause significant problems with breastfeeding. It also causes speech and oral motor problems. The prevalence of ankyloglossia is approxi-mately 4% in babies, and tongue tie is estimated to affect 489,343 newborns, rep-resenting 10% of the Indonesian newborn population of 4,893,435.1 For reasons unknown, this condition is seen more often in males than in females. Ankylo-glossia may be isolated or accompanied by cleft palate (CPX). The presentation of this condition is associated with nucleotide base substitution mutations in the TBX22 gene and the G-protein-coupled receptor Lgr5 and can be related to epi-genetic modification, including DNA methylation and SUMOylation, which is one kind of histone modification.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Lili Nur Indah Sari
AU  - Elza Ibrahim Auerkari
PY  - 2018/05
DA  - 2018/05
TI  - Molecular Genetics and Epigenetics of Ankyloglossia
BT  - Proceedings of the 11th International Dentistry Scientific Meeting (IDSM 2017)
PB  - Atlantis Press
SP  - 103
EP  - 115
SN  - 2468-5739
UR  - https://doi.org/10.2991/idsm-17.2018.14
DO  - 10.2991/idsm-17.2018.14
ID  - Sari2018/05
ER  -