Proceedings of the 2nd International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2020)

Spleen Histopathological Study of Mice (Mus musculus) Infected with Plasmodium berghei After Treatment with Malacca Leaves extract (Phyllantus emblica)

Authors
Amalia Sutriana, Rasmaidar, Nuzul Asmilia, Cut Nila Thasmi, Dwinna Aliza, Wahid Muharram
Corresponding Author
Amalia Sutriana
Available Online 21 April 2021.
DOI
10.2991/absr.k.210420.043How to use a DOI?
Keywords
Malacca leaves extract, spleen, mice, Plasmodium berghei
Abstract

This study aimed to evaluate the effect of ethanolic extract of malacca leaves (Phyllantus emblica) on histopathology of mice (Mus musculus) spleen infected with Plasmodium berghei (P. berghei). This study used 15 male Balb/c strain mice aged 2 months, allotted into 5 treatment groups. The mice in group 1 (P0) were infected with P. berghei without administration of Malacca leaves extract, while the mice in group 2 (P1) were infected with P. berghei and treated with 5 mg/kg BW of chloroquine. The mice in group 3 (P2), 4 (P3), and 5 (P4) were infected with P. berghei and treated with Malacca leaves extract at doses of 100, 300, and 600 mg/kg BW, respectively. At day 7th, all mice were sacrificed, then the spleen were collected for histopathological examination. The observation was carried out on the hemosiderin accumulation, lymphocyte depletion, hemorrhage, and megakaryocyte cells. Data were analyzed using one way analysis of variance (ANOVA). The results showed that the amount of hemosiderin, lymphocyte depletion, and hemorrhage decreased in mice given Malacca leaves extract compared to those in the negative control. In conclusion, the administration of ethanolic extract of malacca leaves reduce the damage of mice spleen due to P. berghei infection

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

Volume Title
Proceedings of the 2nd International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2020)
Series
Advances in Biological Sciences Research
Publication Date
21 April 2021
ISBN
978-94-6239-367-7
ISSN
2468-5747
DOI
10.2991/absr.k.210420.043How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Amalia Sutriana
AU  - Rasmaidar
AU  - Nuzul Asmilia
AU  - Cut Nila Thasmi
AU  - Dwinna Aliza
AU  - Wahid Muharram
PY  - 2021
DA  - 2021/04/21
TI  - Spleen Histopathological Study of Mice (Mus musculus) Infected with Plasmodium berghei After Treatment with Malacca Leaves extract (Phyllantus emblica)
BT  - Proceedings of the 2nd International Conference on Veterinary, Animal, and Environmental Sciences (ICVAES 2020)
PB  - Atlantis Press
SP  - 199
EP  - 203
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.210420.043
DO  - 10.2991/absr.k.210420.043
ID  - Sutriana2021
ER  -